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Becton Dickinson Precise WTA Kits for Single-Cell Research

Becton Dickinson has launched the BD Precise WTA kits, which provide an easier method to identify and quantify genetic information in single cells. The kits include specialized reagents that can extract RNA molecules from individual cells and then "tag" each molecule with a unique molecular signature. Researchers stain a sample with dyes and insert the treated sample into a flow cytometer where the cells are lysed, barcoded, and further prepared for sequencing. Once sequenced, the cell data is processed and analyzed by a proprietary analysis pipeline specific for RNA quantification.

The Scan

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.

Sequencing Study Leads to Vaccine Target in Bacteria Behind Neonatal Meningitis

Researchers eBioMedicine track down potential vaccine targets with transposon sequencing on mutant bacteria causing neonatal meningitis in mouse models of the disease.

Multiple Myeloma Progression Influenced by Immune Microenvironment Expression

Researchers in NPJ Genomic Medicine compare RNA sequencing profiles of 102,207 individual cells in bone marrow samples from 18 individuals with rapid or non-progressing multiple myeloma.

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.