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Avacta Anti di-Ubiquitin K6 and K33 Affimers

Avacta has released Anti di-Ubiquitin K6 and K33 Affimers. Affimer binders are produced entirely in vitro and are therefore not restricted by the host immune system. The technology is suited for difficult targets such as K6 and K33, the exact function of which is largely unknown due to the limited tools available. The Anti di-Ubiquitin Affimer range is human-specific and includes a variety of tagged binders displaying high affinities for poly-ubiquitin chains formed by K6 or K33 linkages, in protein expression studies.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.