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ArcherDX's VariantPlex p53 Panel for Targeted NGS

ArcherDX has expanded the application of its Anchored Multiplex PCR (AMP) technology to include DNA variant detection with the Archer VariantPlex p53 panel. The panel is a targeted next-generation sequencing-based assay to detect germline and somatic mutations of the TP53 gene, which is frequently mutated in cancer. The assays' use a simple lyophilized workflow optimized to minimize hands-on time and contamination risk during library preparation, making them ideal for high-volume laboratories, said ArcherDX in a statement. The AMP-enabled VariantPlex panels are target enrichment assays used to create libraries for Illumina or Ion Torrent sequencing from small amounts (10-200ng) of nucleic acid extracted from formalin-fixed, paraffin-embedded (FFPE) clinical samples. Once sequenced, the Archer Analysis software provides comprehensive analysis with embedded QC metrics and read visualization to accurately detect and identify known and novel fusions, single nucleotide variants, insertion/deletions and copy number variants.

The Scan

Machine Learning Helps ID Molecular Mechanisms of Pancreatic Islet Beta Cell Subtypes in Type 2 Diabetes

The approach helps overcome limitations of previous studies that had investigated the molecular mechanisms of pancreatic islet beta cells, the authors write in their Nature Genetics paper.

Culture-Based Methods, Shotgun Sequencing Reveal Transmission of Bifidobacterium Strains From Mothers to Infants

In a Nature Communications study, culture-based approaches along with shotgun sequencing give a better picture of the microbial strains transmitted from mothers to infants.

Microbial Communities Can Help Trees Adapt to Changing Climates

Tree seedlings that were inoculated with microbes from dry, warm, or cold sites could better survive drought, heat, and cold stress, according to a study in Science.

A Combination of Genetics and Environment Causes Cleft Lip

In a study published in Nature Communications, researchers investigate what combination of genetic and environmental factors come into play to cause cleft lip/palate.