ArcherDX's VariantPlex p53 Panel for Targeted NGS
ArcherDX has expanded the application of its Anchored Multiplex PCR (AMP) technology to include DNA variant detection with the Archer VariantPlex p53 panel. The panel is a targeted next-generation sequencing-based assay to detect germline and somatic mutations of the TP53 gene, which is frequently mutated in cancer. The assays' use a simple lyophilized workflow optimized to minimize hands-on time and contamination risk during library preparation, making them ideal for high-volume laboratories, said ArcherDX in a statement. The AMP-enabled VariantPlex panels are target enrichment assays used to create libraries for Illumina or Ion Torrent sequencing from small amounts (10-200ng) of nucleic acid extracted from formalin-fixed, paraffin-embedded (FFPE) clinical samples. Once sequenced, the Archer Analysis software provides comprehensive analysis with embedded QC metrics and read visualization to accurately detect and identify known and novel fusions, single nucleotide variants, insertion/deletions and copy number variants.