Skip to main content
Premium Trial:

Request an Annual Quote

ArcherDX PreSeq QC Assays

ArcherDX has launched PreSeq QC assays, which assess the quality of nucleic acid in FFPE samples prior to library creation for next-generation sequencing-based mutation detection. These assays are available for both RNA and DNA inputs. The PreSeq QC assays utilize qPCR to measure the quantity of nucleic acid that is of sufficient quality to be amplified into a library that will produce useful NGS data. They help predict successful library construction and provide sample-specific input recommendations to rescue low-quality samples, said ArcherDX in a statement. Similarly, the PreSeq RNA QC Assay predicts the amount of amplifiable cDNA template suitable for fusion detection, thereby predicting fusion assay sensitivity and specificity. The QC score generated with the assay correlates with library complexity metrics generated using the Archer Analysis bioinformatics platform; it also correlates with the accuracy of mutation detection, which enables independent measurement of confidence in variant calling and improves analytical sensitivity and specificity of the assay, said ArcherDX in a statement. All assays integrate into the Archer FusionPlex (RNA input) and VariantPlex (DNA input) assay workflows, but can also be used independent of Archer NGS library preparation panels.

The Scan

WHO Seeks Booster Pause

According to CNN, the World Health Organization is calling for a moratorium on administering SARS-CoV-2 vaccine boosters until more of the world has received initial doses.

For Those Long Legs

With its genome sequence and subsequent RNAi analyses, researchers have examined the genes that give long legs to daddy longlegs, New Scientist says.

September Plans

The New York Times reports that the US Food and Drug Administration is aiming for early September for full approval of the Pfizer-BioNTech SARS-CoV-2 vaccine.

Nucleic Acids Research Papers on Targeting DNA Damage Response, TSMiner, VarSAn

In Nucleic Acids Research this week: genetic changes affecting DNA damage response inhibitor response, "time-series miner" approach, and more.