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ArcherDx Immunoverse

ArcherDx has launched Archer Immunoverse, a suite of immune repertoire sequencing assays. The targeted panels analyze RNA using Archer's patented Anchored Multiplex PCR (AMP) chemistry for open-ended amplification from molecular barcoded adaptors and next-generation sequencing to characterize the immune repertoire. After sequencing, the Immune Repertoire pipeline is used to identify clonotypes. The workflow requires less than 3.5 hours of hands-on time and between 25 nanograms and 2 micrograms of input RNA from peripheral blood mononuclear cells, formalin-fixed paraffin-embedded tissue, or fresh frozen tissue.

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.