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Allelica Coronary Artery Disease Risk Calculator

Allelica has launched a cloud-based tool to enable clinical labs and healthcare providers to calculate an individual's lifetime risk of developing coronary artery disease based on the integration of genetic and traditional risk factors. Built on a secure GDPR- and HIPAA-compliant platform, the technology integrates a newly developed genome-wide polygenic risk score (PRS) for CAD into the pooled cohort equation model. It allows physicians to provide patients with highly customizable visual representations of their risk levels compared to the general population. Users can modify risk factors, like decreases in LDL cholesterol, to show patients how manageable lifestyle changes can actively lower their lifetime risk of heart disease. The calculator was developed and validated using UK Biobank data resources and is the latest addition to Allelica's cloud-based PRS pipeline.

The Scan

Another Resignation

According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug.

Novavax Finds Its Vaccine Effective

Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19.

Can't Be Used

The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports.

PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More

In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.