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Agilent 6545XT AdvanceBio LC/Q-TOF MS System and Peptide Plus Column

Agilent Technologies has released a new mass spectrometry instrument designed for biomolecule characterization in drug development research. The research-grade 6545XT AdvanceBio pairs high-performance liquid chromatography with quadrupole time-of-flight mass spec and the firm's data-analysis tools. Agilent has also optimized the instrument for profiling intact proteins, mapping peptides, and identifying post-translational modifications. The firm also launched the new Peptide Plus LC column for peptide separations, incorporating superficially porous particle technology.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.