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Advanced Cell Diagnostics RNAscope 2.5

Advanced Cell Diagnostics has launched RNAscope 2.5, a next-generation in situ hybridization assay for RNA biomarker analysis in FFPE tissue. The new assay incorporates many refinements and enhancements to enable rapid, accurate assessment of tissue-based biomarker expression across the full spectrum of FFPE clinical tissue samples at unprecedented levels of consistency and reproducibility without the need for lengthy rounds of assay optimization, said ACD in a statement. 

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.