Aalto Bio Zika Virus Antigens

Nov 19, 2015

Aalto Bio Reagents has launched Zika virus antigens. Zika virus is a single-stranded RNA virus transmitted by the Aedes mosquito. It is a flavivirus related to yellow fever virus, dengue virus, chikungunya, and West Nile virus. The first outbreaks in humans were reported in 1957. Over the past ten years, there have been periodic outbreaks across countries in the Southern Hemisphere and one major epidemic in French Polynesia. Aalto Bio is offering the complete suite of Zika virus antigens to diagnostic test manufacturers and researchers to complement the company's dengue antigens and chikungunya antigens, said the company in a statement. 

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Oct 19, 2017

Benson Hill Biosystems 'Edit' System for Crops

Benson Hill Biosystems has launched the Edit system, a complete genome editing system for the development of improved crops. The Edit system combines the analytical power of Benson Hill's CropOS computational platform with a robust portfolio of novel genome editing nucleases to create the first comprehensive genome editing system, the company said. Edit is designed to optimize plant characteristics such as flavor profiles, nutrient-density, and environmental sustainability with greater speed and precision than previously possible. 

Oct 19, 2017

Thermo Fisher Scientific Axiom Africa Array

Thermo Fisher Scientific announced the commercial launch of the Applied Biosystems Axiom Africa Arrray for medical and population genomics to accelerate and support initiatives in global health and population research. The Wellcome Trust Sanger Institute and Thermo Fisher co-developed the array, which  captures genome-wide variation in African populations, as well as Asian and European populations. The array leverages content from the African Genome Resource, and as such contains 925,000 variants, tagging at least 90 percent of common genetic variation in 12 African populations. It also includes pre-selected evidence-based genetic variants important in the context of disease research and pharmacogenomics in global populations. 

Oct 19, 2017

TTP/Sphere Fluidics Cyto-Mine Single-Cell Analysis System

TTP and Sphere Fluidics have launched the Cyto-Mine Single-Cell Analysis System, which automates single-cell analysis, sorting, imaging, and dispensing to help boost throughput and sensitivity throughout the biopharmaceutical discovery process. The platform is based on proprietary algorithm software and optical hardware from Sphere Fluidics, which enables single-cell compartmentalization and fluorescence-assisted sorting. The instrument is compatible with the Cyto-Cartridge, a disposable microfluidic biochip that integrates Sphere Fluidics' picodroplet generation and sorting technology with TTP's dispensing technology. The Cyto-Cartridge allows single cells of interest to be dispensed into individual wells of a microtitre plate for biopharma discovery, cell line development, and monoclonality assurance.

Oct 19, 2017

PerkinElmer Chemagic Prime

PerkinElmer has launched its Chemagic Prime automated nucleic acid isolation and assay setup instrument, which combines the company's Chemagic 360 instrument with the Janus automated liquid handling system. Researchers specializing in biobanking, genetics, and next-generation sequencing can use Chemagic Prime to streamline and automate high-quality DNA and RNA extraction for a wide range of human samples. Obtained nucleic acids can be used for a variety of downstream assays, such as NGS, genotyping, PCR, and MLPA, the firm said.

Chemagic Prime uses magnetized rods rather than magnetic plates to separate nucleic acids from solutions. This reduces the risk of contamination and isolates DNA and RNA that is more pure and intact. The instrument also incorporates additional liquid handling capabilities, which automates primary sample transfer, normalization, and setup of PCR assays and NGS libraries. Chemagic Prime can be paired with PerkinElmer's reagent kits for isolating nucleic acids from a variety of human samples, including whole blood, saliva, plasma, tissues, FFPE samples, and feces. 

Oct 19, 2017

Agilent SureGuide Pooled CRISPR Libraries

Agilent Technologies has launched the first expansion of its SureGuide pooled CRISPR libraries for functional genomics, and is now offering pooled libraries for CRISPR activation and interference. The SureGuide CRISPR libraries are synthesized using Agilent's SurePrint DNA synthesis platform, which simultaneously prints billions of DNA bases. The new CRISPR a/i libraries incorporate gene targets developed by researchers at UCSF, Agilent said.

SureGuide CRISPR a/i libraries are offered in both Ready-to-Clone and Ready-to-Amplify formats. With Ready-to-Clone libraries, scientists can specify the sequence of each guide in the library or choose from validated predefined subsets of the genome, such as kinases or cancer genes. With Ready-to-Amplify libraries, investigators can fully design every aspect of the library, including the tracer sequence, allowing for the use of alternative delivery systems, guide structures, and cloning approaches, while targeting any organism of choice.

Oct 19, 2017

Tempus xT Cancer Genome Sequencing Panel

Tempus has introduced Tempus xT, a genome sequencing panel that analyzes 595 genes related to diagnosis, prognosis, and therapeutic targeting of cancer. Among other things, the panel looks for single-nucleotide variants, small insertions and deletions, amplifications of copy numbers, and structural alterations that could cause fusions, the company said. Chicago-based Tempus will run the xT panel at its own next-generation sequencing lab.

Oct 18, 2017

Illumina NovaSeq S4 Flow Cell, Xp Workflow

Illumina has launched its S4 flow cell and reagent kit for its NovaSeq 6000 next-generation sequencing instrument and plans to launch its NovaSeq Xp workflow before the end of the year.

The S4 flow cell can deliver up to 6 terabases of data, equivalent to up to 48 human genomes or 384 exomes, in two days. The Xp workflow includes the Xp flow cell loading dock and reagents and enables users to load libraries directly onto individual flow cell lanes, which enables users to mix library types or different approaches for sample indexing. 

Oct 17, 2017

Phosphorus Elements Genetic Testing Software

Computational genomics company Phosphorus has introduced Elements, a software platform with six different modules for managing various processes of diagnostic genetic testing. The software-as-a-service platform is aimed at laboratories, community hospitals, and health centers looking to start up genomics and precision medicine programs.

Oct 17, 2017

Desktop Genetics DESKGEN Series CRISPR Libraries

Desktop Genetics launched its DESKGEN Series CRISPR Libraries to support gene editing efforts in academic and biopharma settings. The series consists of six new CRISPR library products, each of which can be tailored to an investigator's list of genomic targets using any delivery method. Each product addresses a particular experimental application of the genome editing technology, the company said. Disrupt Libraries can be used to functionally knock out genes to reveal novel druggable targets and essential pathways; Tile Libraries saturate coding and non-coding regions to reveal genotype-phenotype relationships; SNP-In Libraries allow high-throughput insertion and deletion knockins across the genome; Interfere Libraries silence target gene expression with CRISPRi; Activate Libraries allow over-expression of target genes with CRISPRa; and Predict Libraries provide a unique scoring algorithm optimized for teams working on specific model cell lines or organisms, enabling other libraries to be designed more effectively.

Once the company receives a customer's list of targets, it designs the library using its proprietary DESKGEN AI and suite of bioinformatics pipelines. Once the designs are complete, the company manufactures the library in a variety of ready-to-use formats including plasmids, RNA, ribonucleoproteins, or as lentivirus, in either pooled or arrayed format.

Oct 16, 2017

Genomenon Mastermind Search Engine

Genomenon has announced the limited availability of a free version of its Mastermind genomic search engine for clinical, research, and academic institutions. The free offering lacks some of the features of Mastermind Professional Edition, including genomic data analysis services and workflow automation tools, but it has the same targeted search of genomic research that filters out results not clinically relevant to those interested in genetic relationships to specific diseases. For now, Mastermind Free Edition is available by invitation only. 

Oct 13, 2017

Swift Biosciences Accel-Amplicon Custom NGS Panels

Swift Biosciences has launched Accel-Amplicon Custom NGS Panels, a targeted DNA sequencing product that enables clinical researchers to rapidly design highly focused panels to discover, validate, and screen disease genes and their variants. The platform-agnostic panel supports a wide range of input sample types including fresh and fresh-frozen tissue, whole blood, blood spot cards, formalin-fixed paraffin-embedded tissue, cell-free DNA, circulating tumor DNA, buccal swabs, whole genome amplified DNA and purified DNA. The panels require 10 nanograms of sample input, and enables library prep in under two hours. Swift said that it also partnered with informatics firm Genialis to integrate alignment, trimming, QC, and variant calling into one simple pipeline.

Oct 12, 2017

GenePOC Group B Streptococcus Direct Swab

GenePOC launched its Group B Streptococcus Direct Swab molecular test in Europe. The assay is for use on Revogene, the firm's microfluidic real-time PCR instrument, and will help minimize the risk of GBS transmission from mother to baby. It also will help to optimize antibiotic stewardship, said GenePOC, a member of the Debiopharm Group. 

Oct 11, 2017

iGenomX Riptide High-Throughput Rapid Library Prep Kit

iGenomX has launched Riptide High-Throughput Rapid Library Prep (HT-RLP), which allows users to create up to 960 next-generation sequencing libraries in a short time and at low cost. According to the company, the protocol is simple, easy to automate, and avoids cumbersome processing steps such as fragmentation, repair, and DNA ligation. The kit is intended for use with small genomes and synthetic DNA constructs for applications such as microbiome screening, whole-genome sequencing of microbial genomes, quality control of synthetic DNA products, and high-throughput genotyping by sequencing.

Oct 09, 2017

Fast Track Diagnostics Enteric Fever Kit

Fast Track Diagnostics has launched a kit to detect the pathogens that cause enteric fever, also known as typhoid or paratyphoid fever. The FTlyo Enteric fever kit includes blood collection tubes containing a proprietary Salmonella enrichment broth, ready-to-use multiplex PCR for detection of Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi, and an internal control. The reagents required for the PCR are lyophilized in single-patient sample tubes that can be stored at room temperature, and clinicians need only add extracted nucleic acids to begin the eight-hour detection workflow.

Oct 06, 2017

Xifin LIS Anywhere NGS Module

Xifin has added a next-generation sequencing model to its LIS Anywhere laboratory information system to support precision medicine. The new module, which will be on display at the College of American Pathologists annual meeting, is intended to help labs build their molecular diagnostics capabilities and improve genomics workflow.

The US Food and Drug Administration has approved Kite Pharmaceuticals' CAR T-cell therapy for large B-cell lymphomas, the New York Times reports.

Kaiser Health News reports that gene therapies could cost more than a million dollars.

Worcester Polytechnic Institute researchers have received a grant to combine biology and computer science for high school students.

In Nature this week: variants associated with obsessive-compulsive disorder, review of key CRISPR enzymes, and more.