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10x Genomics Chromium System

10x Genomics has launched a new Chromium System, an upgrade for existing short-read sequencers. It unlocks critical long-range genomics and cell-by-cell gene expression information, the firm said. The system supports the following applications:

  • Chromium Single Cell 3', which performs deep profiling of complex cell populations with high-throughput digital gene expression on a cell-by-cell basis.
  • Chromium Genome, which provides long-range information on a genome-wide scale, enabling identification of critical variants in heritable disorders and discovery of key alterations in cancer.
  • Chromium Exome, which provides long-range information for phasing structural variant detection and copy number determination, giving researchers access to low-complexity and repetitive regions previously missed with short-read sequencing.
  • The Supernova Assembler, which opens the door to low-cost, everyday diploid de novo assemblies by unlocking sample-specific sequence and produces diploid genome structure.
The Scan

Team Tracks Down Potential Blood Plasma Markers Linked to Heart Failure in Atrial Fibrillation Patients

Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.

Study Points to Synonymous Mutation Effects on E. Coli Enzyme Activity

Researchers in Nature Chemistry saw signs of enzyme activity shifts in the presence of synonymous mutations in a multiscale modeling analysis of three Escherichia coli genes.

Team Outlines Paternal Sample-Free Single-Gene Approach for Non-Invasive Prenatal Screening

With data for nearly 9,200 pregnant individuals, researchers in Genetics in Medicine demonstrate the feasibility of their carrier screening and reflex single-gene non-invasive prenatal screening approach.

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.