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10x Genomics Chromium Single-Cell CNV Solution

10x Genomics has launched the Chromium Single-Cell CNV Solution, a scalable technology for rapid and parallel profiling of single-cell genomes. The solution is built on the firm's technology for generating cell beads and gel beads, and enables preparation of hundreds to thousands of single cells for CNV profiling within minutes on either the Chromium Controller or the Chromium Single-Cell Controller. It profiles the genomes of individual cells and can be used for applications such as revealing tumor heterogeneity, characterizing somatic mosaicism of neurons, and authenticating cell line identity and clonal purity. The product also further examines the clonal structure of cancer samples, including spatial distribution across tumor slices and longitudinal changes.

The Scan

Octopus Brain Complexity Linked to MicroRNA Expansions

Investigators saw microRNA gene expansions coinciding with complex brains when they analyzed certain cephalopod transcriptomes, as they report in Science Advances.

Study Tracks Outcomes in Children Born to Zika Virus-Infected Mothers

By following pregnancy outcomes for women with RT-PCR-confirmed Zika virus infections, researchers saw in Lancet Regional Health congenital abnormalities in roughly one-third of live-born children.

Team Presents Benchmark Study of RNA Classification Tools

With more than 135 transcriptomic datasets, researchers tested two dozen coding and non-coding RNA classification tools, establishing a set of potentially misclassified transcripts, as they report in Nucleic Acids Research.

Breast Cancer Risk Related to Pathogenic BRCA1 Mutation May Be Modified by Repeats

Several variable number tandem repeats appear to impact breast cancer risk and age at diagnosis in almost 350 individuals carrying a risky Ashkenazi Jewish BRCA1 founder mutation.