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10x Genomics Chromium Single-Cell CNV Solution

10x Genomics has launched the Chromium Single-Cell CNV Solution, a scalable technology for rapid and parallel profiling of single-cell genomes. The solution is built on the firm's technology for generating cell beads and gel beads, and enables preparation of hundreds to thousands of single cells for CNV profiling within minutes on either the Chromium Controller or the Chromium Single-Cell Controller. It profiles the genomes of individual cells and can be used for applications such as revealing tumor heterogeneity, characterizing somatic mosaicism of neurons, and authenticating cell line identity and clonal purity. The product also further examines the clonal structure of cancer samples, including spatial distribution across tumor slices and longitudinal changes.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.