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Feb 25, 2021

Twist Bioscience NGS Methylation Detection System

Twist Bioscience has launched the Twist NGS Sequencing Methylation Detection system, a sample preparation and target enrichment solution for identifying methylated regions in the human genome.

The system uses EM-seq from New England Biolabs, an enzyme-based alternative to traditional bisulfite sequencing methods that enables preparation of enzymatically converted libraries. The system also includes Twist methylation enhancer, universal blocker and FastHyb, and custom methylation panels that include DNA probes to capture all four potential sequences at a given site: methylated, unmethylated, sense and antisense.

The products can be used in liquid biopsy cancer analysis and epigenetic studies.

Feb 25, 2021

New England Biolabs Artic Products for SARS-CoV-2 Sequencing

New England Biolabs has launched three kits based on the Artic Network protocols for multiplexed amplicon-based sequencing of viral RNA: NEBNext Artic SARS-CoV-2 Library Prep Kit and NEBNext ARTIC SARS-CoV-2 FS Library Prep Kit, both for Illumina sequencing; and NEBNext Artic SARS-CoV-2 Companion Kit for Oxford Nanopore Technologies sequencing.

The Artic network is an international research consortium that has developed protocols for the epidemiological monitoring of viral genomes to provide insights into virus evolution and transmission. All three NEBNext Artic SARS-CoV-2 kits yield uniform, ample amplicons from gRNA across a wide copy number range, and use the same RT step for all inputs, NEB said. The two kits for Illumina sequencers provide options for library insert size and downstream sequencing parameters.

Feb 24, 2021

Promega LMR MSI Analysis System

Promega has launched its LMR MSI Analysis system, a PCR-based research tool with novel markers for detecting microsatellite instability. The panel consists of eight total markers: four gold-standard markers (BAT-25, BAT-26, MONO-27, and NR-21) and four novel long mononucleotide repeat markers (BAT-52, BAT-56, BAT-59, and BAT-60). According to the company combining these marker sets expands MSI detection ability in difficult samples while maintaining overlap with data gathered using traditional markers. Promega said that the assay has been optimized to enable strong and balanced amplification even from degraded samples such as formalin-fixed, paraffin-embedded tissue.

Feb 22, 2021

NanoString Technologies Whole Transcriptome Atlas

NanoString Technologies has announced the commercial availability of its Whole Transcriptome Atlas (WTA) for research using human tissue on the GeoMx digital spatial profiler.

The WTA provides an unbiased, spatial view of all protein-coding genes and is designed for next-generation sequencing readout on Illumina sequencers. It works with formalin-fixed paraffin-embedded or fresh frozen samples.

The company also announced that it is launching the WTA for mouse tissue through its GeoMx technology access program.

Feb 19, 2021

Guardant Health Guardant Reveal

Guardant Health has launched Guardant Reveal, a blood-based liquid biopsy test for the detection of residual and recurrent disease in cancer patients. Intended initially for the early-stage colorectal cancer space, the assay detects circulating tumor DNA in patients' blood to identify those with residual disease who may benefit most from adjuvant therapy and/or detect the first signs of a recurrence. Results are returned in as little as seven days without the need for a tissue biopsy.

Feb 18, 2021

Parse Biosciences Single-Cell Whole Transcriptome Kit

Parse Biosciences, formerly known as Split Biosciences, has launched its Single-Cell Whole Transcriptome kit in North America.

The kit, which requires only basic lab equipment, enables single-cell transcriptomics for up to 100,000 cells or nuclei across 48 samples. Samples can be fixed for up to six months prior to barcoding and sequencing. The method is based on the split-pool ligation-based transcriptome sequencing (SPLiT-seq) method. Customers purchasing the kit will receive access to the Parse computational pipeline, an out-of-the box software tool that can be run locally.

Feb 17, 2021

Menarini Silicon Biosystems CellMag Product Line

Menarini Silicon Biosystems has launched its CellMag product line. The line includes the CTC Epithelial Cell kit for ferrofluid-based EpCAM-positive circulating tumor cell enrichment, a magnetic tool, and consumables. The firm believes the product line will help researchers conduct specific, established, and standardized immunomagnetic enrichment and staining of CTCs in peripheral blood. After positive selection of enriched cells, performed by capturing cells through ferrofluids labeled with antibodies targeting specific antigens, the staining procedure delivers cells that are ready for enumeration, isolation, and downstream analysis. Menarini said the CellMag line provides researchers with a manual system using the same ferrofluid technology offered by its CellSearch system.

Feb 17, 2021

CellPort Software Cell Culture Suite

CellPort Software has launched the CellPort Cell Culture Suite, a cloud-based software-as-a-service product for cell culture and cell banking. The product is a secure, compliant application suite designed to manage all lab workflows, activities, equipment, materials, personnel, data/calculations, locations, and projects for cell culture and cell banking.

Feb 16, 2021

Verogen ForenSeq Kintelligence Kit

Forensic genomics firm Verogen has launched the ForenSeq Kintelligence Kit for genetic genealogy. The next-generation sequencing-based workflow runs on the Illumina MiSeq FGx system and targets 10,230 SNPs curated for forensics while minimizing medically informative markers. It is also integrated with GEDmatch PRO genealogy database.

Feb 12, 2021

Active Motif Hi-C Epigenetic Service

Active Motif has launched an end-to-end Hi-C service built on Arima Genomics' Hi-C kits. Hi-C is used by the research community and multiple large consortia such as ENCODE and 4D Nucleome to investigate how genome folding and misfolding impacts gene accessibility, regulation, and expression, and its impact on disease states. Under an agreement with Arima, Active is launching its Active Motif Epigenetic Service to serve academic, pharma, and clinical researchers.

Feb 12, 2021

SeqWell PlexWell Single-Cell Rapid Kit

SeqWell has launched its PlexWell Single-Cell Rapid Kit for the preparation of next-generations sequencing libraries for single-cell RNA sequencing. The kit improves upon the Smart-seq2 method by combining cDNA synthesis and amplification, and reducing the QC and normalization burden by 75 percent to achieve a single-day library prep workflow. This simplified approach can produce sequencing-ready, full-length transcriptome libraries from hundreds to thousands of sorted cells at a time, the company said. Other features include iterative barcoding and auto-normalization to create balanced library pools without the need for further sample or library normalization. The method has been optimized for low cDNA inputs to maintain library complexity, improve detection of low-abundance targets, and preserve variant and isoform information, the company said.

Feb 12, 2021

Genomind GenMed Pro Smarter Precision Gene-Drug Interaction Software

Genomind has launched its GenMed Pro Smarter Precision Gene-Drug Interaction Software, medication management software designed to work in tandem with the company's Genomind Professional PGx Express pharmacogenetic test. GenMed Pro covers the most commonly prescribed medications for the top healthcare conditions. These medications are assesses with key genes that can impact a patient's metabolism, absorption, and sensitivity. The software will be available at no additional cost to healthcare providers who register for Genomind's Clinician Portal.

Feb 11, 2021

Zymo Research COVID-19 Variant Sequencing Service

Zymo Research has launched its COVID-19 Variant Sequencing Service. The workflow consists of sample collection from testing centers, automated RNA extraction using KingFisher Flex robotics, sequencing with Illumina's COVIDSeq NGS workflow including analysis with the Dragen COVIDSeq analysis pipeline, and reporting. The final report includes COVID-19 strain identification, genome sequencing coverage, confirmed mutations, consensus genome, and raw sequence files. Zymo uses its DNA/RNA Shield preservative to inactivate the SARS-CoV-2 virus and stabilize its RNA.

Feb 09, 2021

Tempus xG

Tempus has launched a new germline sequencing assay, xG, a 52-gene panel that specifically identifies genetic variants associated with hereditary cancer syndromes and inherited risk of cancer. The test is performed by BioReference Laboratories' subsidiary GeneDx and joins Tempus' existing suite of oncology-focused testing offerings, including tumor and liquid biopsy tests, HRD, and TO (tumor of unknown origin) assays.

Feb 03, 2021

Swift Biosciences Normalase Amplicon SARS-CoV-2 S Gene Panel

Swift Biosciences has released the Normalase Amplicon SARS-CoV-2 S Gene Panel (SNAP), a targeted gene panel that covers 100 percent of the SARS-CoV-2 S gene even with limited viral titers. The new panel eliminates the need to perform qPCR for library normalization for downstream sequencing, Swift said.

Feb 03, 2021

Cardio Diagnostics Epi+Gen CHD Heart Disease Risk Assessment Test

Cardio Diagnostic has launched Epi+Gen CHD, a heart disease risk assessment test. Potential patients fill out a screening questionnaire that is reviewed by a board-certified clinician. If eligible for the test, a sampling kit is sent to the patient's home. After the sample is collected, it is shipped to a partner CLIA-certified lab for processing. After approval by a board-certified pathologist, the results are released to the ordering clinician for review and discussion with the patient. According to Cardio Diagnostics' website, the measures DNA methylation status at three specific loci and genotype at five loci. An artificial intelligence-guided algorithm interprets the results of the DNA methylation contextually with respect to the genetic variation, allowing it to interpret epigenetic signatures that would otherwise be confounded by background genetic variation, the company said.

Feb 02, 2021

MediSapiens Genomics Software Suite

MediSapiens has introduced MediSapiens Genomics Software Suite (GSS), an analytics platform that integrates genomic, phenotypic, and other clinical data from multiple sources. The cloud-based GSS platform can assist researchers in cohort building, risk scoring, and obtaining patient consent, according to the Finnish company. MediSapiens GSS can be used for population research, drug discovery, and personalized medicine.

Feb 02, 2021

Enpicom ImmunoGenomiX Platform With Antibody Discovery Mode

Netherlands-based Enpicom has released its ImmunoGenomiX (IGX) bioinformatics platform with an antibody discovery module. The IGX platform is designed to manage, analyze, integrate, and visualize immune repertoire sequencing data in a single environment. It is technology-agnostic and code-free, and enables scientists to securely analyze immune repertoires, the company said. The new antibody discovery module applications are IGX-Cluster and IGX-Branch. IGX-Cluster groups sequences based on user-defined parameters such as CDR3 similarity, gene usage, and CDR3 length. It performs large clustering tasks in the cloud and supports a wide variety of workflows for both paired and unpaired receptor chains. Subsequently, IGX-Branch creates interactive visualizations to prioritize clusters and pick antibody candidates for follow-up analysis through information-rich phylogenetic trees.

Jan 28, 2021

Qiagen QiAcuity One-Step Viral RT-PCR Kit for Wastewater Testing

Qiagen has launched a dedicated RT-PCR kit for SARS-CoV-2 wastewater testing on the company's QiAcuity Digital PCR platform. QiAcuity precisely quantifies minimal quantities of DNA and RNA, making it ideal for research tests for viruses, bacteria, or genetic disorders. The platform is available in a one-plate, four-plate, and eight-plate version, all of which feature flexible sample throughput and the ability to simultaneously detect up to five target sequences. This enables the QiAcuity Eight, for instance, to process up to 1,248 samples in one working day, Qiagen said.

Jan 28, 2021

PerkinElmer Assay Kits for GPCR Therapeutic Discovery

PerkinElmer has launched new assay kits to further G protein-coupled receptor (GPCR) therapeutics discovery. The kits include the HTRF GTP Gi binding kit (a time-resolved Förster resonance energy transfer-based assay for GTP binding); the B-arr2 recruitment kit; and HTRF total kits for beta-arresting 1, beta-arrestin 2, and AP2. The assays are intended to help scientists better understand the role GPCRs play in disease by studying the interaction, expression, and potential modulation of intracellular proteins involved in GPCR signaling mechanisms.

Jan 27, 2021

NRichDx Revolution Sample Prep Semi-Automated Workflow

NRichDx has launched its semi-automated Revolution Sample Prep Workflow, powered by Eppendorf's epMotion 5073 instrument, for extraction of cell-free and circulating tumor DNA from a wide range of input sample volumes. The firm has designed the workflow to increase yield, sensitivity, and throughput by delivering more target cfDNA and ctDNA for molecular assays with increased automation and reduced hands-on technician time. The workflow allows for extraction from batches of eight to 24 samples in as little as three hours. 

Jan 27, 2021

Clear Labs Clear Dx Whole-Genome Sequencing Kit for SARS-CoV-2

Clear Labs has launched the Clear Dx whole-genome sequencing solution for enhanced screening and genomic surveillance of SARS-CoV-2.

Intended for use with samples that have already tested positive for SARS-CoV-2 by another method, the automated next-generation sequencing assay provides the complete RNA genome of the virus in less than 24 hours with approximately 30 minutes of hands-on time. The kit is for research use only.

Jan 26, 2021

Bionano Genomics: Compute on Demand (COD) 1.2

Bionano Genomics has released version 1.2 of its Compute on Demand (COD) cloud compute solution. According to the company, it significantly reduces the cost and time to analyze structural variants in a human genome. Analysis results are now returned in nine hours, a 30 percent reduction in time. The improvements are enabled by the use of Microsoft Azure as a high-performance computing provider, adding to existing provider Amazon Web Services.

Jan 25, 2021

NIPD Genetics: Oreana Neonatal Genetic Screening Test

NIPD Genetics of Cyprus has launched Oreana, an expanded genetic screening test for newborns, infants, and children. The sequencing test screens for 106 genetic conditions in 142 genes, based on recommendations from the American College of Medical Genetic and Genomics. It requires a buccal swab and has a turnaround time of two to three weeks from sample receipt.

Jan 19, 2021

Thermo Fisher Scientific Invitrogen Intact Virus Precipitation Reagent, Dynabeads Intact Virus Enrichment Kits

Thermo Fisher Scientific has launched the Invitrogen Intact Virus Precipitation Reagent and the Dynabeads Intact Virus Enrichment Kits. Both are optimized to isolate intact SARS-CoV-2 virus particles, including infectious virus, inactivated virus, and virus-like particles. The Intact Virus Precipitation Reagent isolates intact SARS-CoV-2 virus from large, dilute samples in three steps that take less than three hours. The Intact Virus Enrichment Kits allow for high-throughput enrichment of virus in less than 20 minutes and can be used with any of the Kingfisher family of instruments. Both products are designed for virology research, immunological and serological viral research, high-throughput virus screening, protein analysis, cell analysis, and nucleic acid research.

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Politico reports that the NYPD DNA database has grown since it announced it would be removing profiles from it.

Forbes reports that a structural biology lab at Oxford University studying the coronavirus was hacked.

Science reports that a Dutch research funding agency is combating a ransomware attack.

In Science this week: set of 64 haplotype assemblies from 32 individuals, and more.