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Feb 25, 2020

Blueprint Genetics Mitochondrial Genome Analysis

Blueprint Genetics, a Quest Diagnostics company, has introduced full mitochondrial genome DNA (mtDNA) analysis to its diagnostic panels to increase diagnostic potential across medical specialties such as cardiology, metabolic disease, neurology, ophthalmology, and hearing loss. The analysis uses hybridization-based capture of mtDNA and next-generation sequencing to detect low heteroplasmy levels of mtDNA SNVs, indels, and deletions. It includes sequencing and copy number variant analysis of the entire mitochondrial genome (37 genes) which can be ordered alone or added to any panel. It has also been added to 30 existing panels where mitochondrial DNA testing is expected to have an impact on the diagnostic potential.

Feb 25, 2020

Seven Bridges Aria

Seven Bridges has introduced Aria, a bioinformatics platform for analyzing genotypic and phenotypic data to inform drug discovery. The cloud-based platform features: extract, transform, and load (ETL) processes for managing and building cohorts from phenotypic data; a variant data warehouse for querying whole-genome sequences; and an interpretation framework. Aria also supports in silico exploration of the impact of inactivating genes.

Feb 25, 2020

Dovetail Genomics Micro-C, HiChIP Kits

Dovetail Genomics has launched the Dovetail Micro-C and HiChIP Kits. The Micro-C Kit is the latest offering in the company's suite of Hi-C products, offering researchers resolution of chromatin contacts down to the mono-nucleosome level. The Dovetail HiChIP combines Micro-C and ChIP-seq into one simple workflow that enables researchers to assay protein-directed alterations to chromatin architecture and its resulting impact on gene expression, the company said. Both products are made for short-read next-generation sequencing platforms.

Feb 25, 2020

Twist Bioscience Comprehensive Exome Panel, Targeted Methylation Sequencing Solution

Twist Bioscience has launched its Twist Comprehensive Exome Panel, an optimal next-generation sequencing target enrichment solution that includes more than 99 percent of protein coding genes. The panel expands on the content of the Twist Human Core Exome to include coverage of protein-coding genes from all three key public genetic databases: CCDS, RefSeq and GENCODE, providing best-in-class coverage of the most up-to-date content, the company said. In addition, the panel can be customized quickly and affordably. Because of the updated and comprehensive coverage, the new panel allows for increased confidence in variant detection experiments, as well as maximum sequencing efficiency and best coverage uniformity.

Twist has also introduced the Twist Targeted Methylation Sequencing Solution to enable the study of methylation pattern changes in research fields including cancer, epigenetics, and non-invasive prenatal testing. The Targeted Methylation Solution offers a high-throughput, highly uniform target enrichment solution to explore methylation. This product is now available for early access customers, the company said. 

Feb 25, 2020

S2 Genomics Singulator 100 System

S2 Genomics this week launched the Singulator 100 System at the Advances in Genome Biology and Technology meeting. The Singulator 100 automates the processing of solid tissue samples into suspensions of single cells or nuclei with high yields and from small samples for a wide range of single-cell biology and genomic analyses. The company said that this enables researchers to reproducibly prepare suspensions of high-quality, highly viable cells or nuclei with minimal variability. The system will begin shipping in spring of this year with kits available for single-cell and nuclei isolation.

Feb 25, 2020

Lexogen: RiboCop rRNA Depletion Kits for Bacteria

Lexogen has developed a set of new RiboCop rRNA Depletion Kits for Bacteria, which it said efficiently remove 23S, 16S, and 5S rRNA from mixed bacterial samples and monocultures. According to the firm, RiboCop is offered as a stand-alone kit with the option to choose from three optimized probe mixes for depletion of either rRNA from mixed bacterial samples, or Gram-negative or Gram-positive bacteria grown in monoculture.

The technology uses a set of affinity probes designed for specific depletion of rRNA sequences, and, according to Lexogen, the probe design minimizes off-target effects that can distort NGS data quality. The kits work with total RNA input amounts as low as 1 ng and up to 1 μg, depending on sample composition and the chosen depletion probe mix. RiboCop does not include any enzymatic reactions or mechanical shearing steps and can process intact as well as degraded material, including FFPE, resulting in intact, full-length transcripts. Resulting rRNA-free samples are then suitable for a variety of downstream RNA analysis methods including RNA-seq library preparation approaches.

The protocol is also automation-friendly, the firm added.

Feb 25, 2020

Promega Corporation: Wizard HMW DNA Extraction Kit

Promega Corporation has launched its Wizard HMW DNA Extraction Kit, a tool for researchers working with large fragments of genomic DNA. According to the company, the new HMW DNA product, which joins the firm's existing portfolio of both manual and automated kits to extract a variety of nucleic acids from a broad range of sample types, allows researchers, in a 90-minute manual protocol, to obtain DNA that can provide strong performance in long-read sequencing applications. Data on this performance was demonstrated in a poster presented at this week's 2020 Advances in Genome Biology and Technology (AGBT) meeting, Promega said. When run through a long-read sequencing protocol, the DNA from the Promega kit produced very long maximum reads and high N50 values, indicating a higher proportion of large fragments in the sample. 

Compared to available alternatives, Promega claimed that the Wizard kit purifies a "significantly higher" proportion of fragments over 125kb. The kit supports purification from a variety sample types including whole blood, bacterial cultures, cultured mammalian cells, and plant leaf tissue.

Feb 21, 2020

Bio-Rad Laboratories: EDX RP Positive Run Control

Bio-Rad Laboratories said that Exact Diagnostics has launched the EDX RP Positive Run Control, an unassayed external quality control for monitoring the performance of clinical respiratory assays. Bio-Rad acquired Exact Dx in the third quarter of 2019. Routine use of the EDX RP Positive Run Control allows labs to meet their individualized quality control goals, such as the evaluation of reagent lot changes and new shipments, Bio-Rad said. The control also monitors multiple identical devices and provides an evaluation of different personnel and locations. It contains 22 respiratory analytes that are internally value-assigned using Bio-Rads Digital Droplet PCR technology and is designed to test the entire process of a molecular assay, including extraction, detection, and amplification. 

Feb 19, 2020

Covaris Viral RNA Extraction Kits

Covaris has launched two new kits for viral RNA extraction from nasal or throat swab sample collection devices. The truXTRAC Viral RNA Extraction kit uses Puritan swabs and contains all components for the firm's adaptive focused acoustics-based extraction as well as magnetic bead-based purification of high-quality RNA from synthetic swabs. The truXTRAC-PCR Direct Viral RNA Extraction kit can be used directly in real time RT-PCR assays without prior purification, provided an internal control is included.

Feb 19, 2020

Integrated DNA Technologies xGen Prism DNA Library Prep Kit

Integrated DNA Technologies (IDT), a Danaher company, has launched the xGen Prism DNA Library Prep Kit, which is designed for challenging and low-quality samples. The kit can convert cell-free DNA and DNA from formalin-fixed paraffin-embedded tissue into high-quality next-gen sequencing libraries. It greatly reduces adapter dimers and uses unique molecular identifiers (UMIs) for enhanced error correction.

Feb 18, 2020

Thermo Fisher Scientific Applied Biosystems PowerTrack SYBR Green PCR Master Mix

Thermo Fisher Scientific has released the Applied Biosystems PowerTrack SYBR Green PCR Master Mix. It is designed for real-time PCR workflows and is compatible with all qPCR instruments. It contains a two-color tracking dye system to help researchers keep track of where they have pipetted. The mix uses an antibody-mediated hot-start mechanism to control activation of the Taq enzyme. It also includes UNG and dUTP enzymes to prevents previously amplified PCR products from contaminating subsequent qPCR reactions. The mix provides results ranging from 0.1 pg to 100 ng of complementary DNA per reaction and can be used in standard or fast cycling mode.

Feb 18, 2020

Nebula Genomics: 30X Whole-Genome Sequencing Service

Nebula Genomics has launched a new, direct-to-consumer whole-genome sequencing service. Performed with MGI DNBSEQ T-Series instruments in BGI's global network of sequencing centers, Nebula's service offers 30X coverage for $299.

Individuals who sequence their genome through Nebula will retain full control of their genomic data, the firm added in a statement.

Feb 13, 2020

PerkinElmer: Sciclone G3 NGSx HT Workstation

PerkinElmer has launched the Sciclone G3 NGSx HT Workstation for automated next-generation sequencing library preparation. The instrument comes with a 384-plex low-volume pipetting head, on-deck thermal elements, a shaker, a thermal cycler, and a robotic pipette tip loader. It can automate cDNA synthesis from RNA or single cells as well as library construction from cDNA or gDNA. DNA-seq libraries can be prepared using the Nextflex Rapid XP DNA-seq kit.

Feb 11, 2020

Living DNA: African Ancestry DNA Test Report

Living DNA, a direct-to-consumer genealogy DNA service, has launched an African ancestry DNA test report that covers 72 regions in Africa. Living DNA said that its report offer five times the African ancestry coverage of any other test, and has been specially designed for African Americans and African Europeans who are researching their roots. The test combines recent ancestry breakdown (last 1,000 years) with deep direct maternal and paternal histories, as well as rich information about the regions from which customers' ancestors originate, covering geography, languages, traditions, and culture. All existing customers with African ancestry can log into their results platform and choose to update their results free of charge, the company said. New customers can purchase a test on offer for Black History Month for $79.

Feb 07, 2020

CDI Labs HuScan and VirScan

CDI Laboratories' Antygen Division, which provides contract research for R&D in the therapeutic and diagnostic space, has launched two biomarker discovery assays, HuScan and VirScan. HuScan detects antibodies against the entire human proteome via long peptides on the surface of bacteriophages, antibody pulldown, and sequencing readouts. VirScan detect antibodies against the proteomes of every viral strain known to infect humans in the same manner. Both assays represent the first commercial use of PhIP-seq technology, the company said.

Feb 06, 2020

CeGaT Exome Xtra

CeGaT has launched the CeGaT Exome Xtra test, which the firm says increases the diagnostic yield compared to a standard exome test. Besides coding sequences, it includes all medically relevant regions throughout the genome, such as pathogenic and likely pathogenic intronic variants, disease-associated transcripts, cryptic exons, as well as the mitochondrial genome. In addition, the data analysis considers variants in genes with reduced penetrance, variable expressivity, imprinting effects, and SNV/CNV combinations.

Feb 06, 2020

Thermo Fisher Scientific Ion Torrent CarrierSeq ECS Kit

Thermo Fisher Scientific has introduced the Ion Torrent CarrierSeq ECS Kit for expanded carrier screening. The AmpliSeq-based panel, which runs on the Ion GeneStudio S5 sequencer, covers 420 genes, including difficult-to-sequence ones like SMN1 and SMN2 for spinal muscular atrophy, GBA for Gaucher disease, CYP21A2 for 21-hydroxylase deficient congenital adrenal hyperplasia, and HBA1 and HBA2 for alpha thalassemia. It detects more than 28,000 non-benign ClinVar variants, including single nucleotide variants and copy number variants, and comes with customizable Carrier Reporter software.

Feb 05, 2020

Hologic Panther Scalable Solutions

Hologic launched new products in the US and Europe within its Panther Scalable Solutions portfolio, in which the firm's molecular diagnostic Panther system functions as the foundation for optional add-ons. The add-on components include Panther Fusion, which launched in 2016 and provides additional IVD menu and an Open Access functionality; Panther Plus and Panther Link, which are now available; and Panther Trax, which is in development.

With Panther Plus, labs can load more consumables directly on the instrument, allowing up to 13.5 consecutive hours of walk-away time. Panther Link is a software solution that provides additional efficiencies by creating a virtual connection that allows multiple Panther instruments to communicate with one another and function within a singular, streamlined workflow. Panther Trax is being developed to physically and electronically link multiple Panther instruments into a single workcell.

Feb 05, 2020

Bio-Techne Next-Generation ELISA Kits

Bio-Techne has launched its Quantikine QuicKit next-generation ELISA product line, which expands the capabilities of its legacy Quantikine ELISA kits. According to Bio-Techne, the kit enables researchers to accomplish more in their day without compromising quality. It enables quantitation of proteins in serum, plasma, and cell supernates in 90 minutes.

Jan 29, 2020

NIPD Genetics Veragene

NIPD Genetics has expanded its Veragene noninvasive prenatal test. The new version of the assay, which covers aneuploidies, microdeletions, and monogenic diseases, is able to identify 2,000 mutations in 99 genes involved in 100 monogenic autosomal recessive and X-linked disorders.  

Jan 27, 2020

Swift Biosciences, Opentrons Labworks Automated 2S Turbo DNA Library Preparation

Swift Biosciences and Opentrons Labworks have launched pre-scripted, automated protocols for the Swift 2S Turbo DNA library preparation kit on the Opentrons OT-2 liquid handler. The protocol can be combined with the Swift Deceleration Module to obtain longer fragments of 550 bp, control fragmentation time on automation platforms, or adjust sample elution buffer.

Jan 27, 2020

Agilent SureSelect XT HS2 DNA Kit

Agilent Technologies has launched its SureSelect XT HS2 DNA kit, which it said will offer researchers a complete solution to choose workflow options. The firm said the kit allows users to multiplex hundreds of samples in one sequencing run, remove sample contamination by indexing from reads, and improve error correction to detect variants with low allele frequencies. 

Jan 27, 2020

Qiagen QCI Precision Insights

Qiagen has launched Qiagen QCI Precision Insights in Europe. QCI Precision Insights is a clinical interpretation service provided by a team of molecular biologists and oncologists who translate patient-specific molecular data into clinical insights and therapeutic options. The new offering includes European Society for Medical Oncology (ESMO) guidelines and the European Medicines Agency (EMA)-approved oncology drugs catalog. Qiagen said that the service enables molecular pathologists and oncologists in Europe to confidently match complex genomic test data to relevant, geographically matched treatment options in minutes for evidence-based, individualized treatment recommendations.

Jan 23, 2020

Integrated DNA Technologies xGen Exome Research Panel v2

Integrated DNA Technologies has launched the xGen Exome Research Panel v2. The next-generation sequencing panel offers improved on-target rates and uniformityincreased sample coverage, updated content, and enhanced performance. The retail price is $8 per sample, which IDT said is a reduction of more than 50 percent compared to the previous version. Each of the panel's 415,115 probes are individually synthesized on IDT's newest platform, Gemini, and manufactured for one large synthesis lot to ensure reproducible results and avoid lot-to-lot revalidations. Potential applications for the assays include population studies, rare disease research, and oncology, IDT said.

Jan 23, 2020

Meridian Bioscience High-Specificity Pfu HS Mix

Meridian Bioscience launched a High-Specificity Pfu Hs Mix to provide high-fidelity amplification for companion diagnostic and clinical testing. The solution cuts down on the possibility of uneven amplification of diverse types of sequences. Meridian said the mix has "market-leading" properties in terms of inhibitor resistance, multiplexing, and low GC bias and can be used in next-generation sequencing and PCR applications. 

Pages

The New York Times looks at companies using genomic tools to try to quickly identify the cause of patients' infections.

The White House has asked for $2.5 billion in funding to address the COVID-19 outbreak, according to the Associated Press.

A resignation at the Marine Biological Laboratory highlights that institutions are unsure of how to handle researchers previously found to have violated codes of conduct, Nature News says.

In PNAS this week: immune responses that affect heart transplant rejection risk, gene variants associated with thiopurine toxicity, and more.