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Mar 22, 2019

Akoya Biosciences Codex System, Phenoptics 2.0

Akoya Biosciences has commercially released Codex, its tissue analysis and biomarker discovery system, and Phenoptics 2.0, its next-generation biomarker multiplexing platform. According to the firm, the new platforms provide scientists with a detailed solution for multiplexing immunofluorescence from discovery through clinical and translational research.

The Codex system includes a fluidics-based instrument, reagents, and a software analysis suite. Users can simultaneously analyze more than 40 protien markers for spatially resolved tissue characterization with single-cell resolution. The firm said that the system allows customers to design custom panels using a combination of Akoya-validated, ready-to-use antibodies and customer antibodies of interest.

According to Akoya, Phenoptics 2.0 uses the Vetra Polaris imaging system, Opal detection reagents, and inForm analysis software. With the release, the firm is introducing its Motif technology, which simultaneously collects multispectral images on whole-slide tissue sections of up to seven colors. Phenoptics 2.0 also includes multispectral analysis of up to nine colors in regions of interest for deeper interrogation of tissue samples.

Mar 21, 2019

Roche Diagnostics Navify Mutation Profiler, Navify Therapy Matcher

Roche Diagnostics has launched Navify Mutational Profiler and Navify Therapy Matcher to support next-gen sequencing-based cancer genomic profiling tests. Both are part of Roche's Navify Decision Support portfolio.

Navify Mutational Profiler is a clinical software that provides annotation, interpretation, and clinical reporting of NGS tests. Navify Therapy Matcher is an optional clinical decision support app that helps clinicians link clinically actionable mutations to therapy options.

Mar 21, 2019

SeqOnce Biosciences RhinoSeq Rapid DNA Library Preparation Kit

SeqOnce Biosciences has launched its RhinoSeq DNA Library Preparation Kit for next-generation sequencing sample preparation. The firm said that the five tube kit contains preformatted master mixes for a simple, fast, and stable workflow. The tool generates a temporary structure that creates sequence-specific single stranded overhangs for sequencing adaptor litigation. When combined with fragmentation and PCR steps, the kit's 12 minute library construction uses a single master-mix that produces libraries in less than 45 minutes. SeqOnce said that the kit produces best results using a DNA input between 5 to 100ng.

Mar 19, 2019

Asuragen AmplideX PCR/CESMN1/2 Kit

Asuragen has launched the AmplideX PCR/CE SMN1/2 kit. Building upon the testing workflow of the AmplideX PCR/CE SMN1 Kit, the new assay quantifies both SMN1 and SMN2 exon 7 copy number in less than four hours from a single PCR reaction. The firm said that the assay shares a common testing workflow with all other assays in the AmplideX portfolio and is similarly optimized for broadly installed Thermo Fisher Scientific Applied Biosystems Genetic Analyzers.

Interest in SMN1 and SMN2 copy number quantification has grown following the 2016 FDA approval of nusinersen (Biogen Idec's Spinraza) for the treatment of spinal muscular atrophy, a disease attributable to loss of functional copies of the SMN1 gene, and the severity of which is inversely correlated with the number of copies of SMN2, Asuragen noted.

Mar 19, 2019

Strata Oncology StrataNGS

Strata Oncology has launched version 3.0 of StrataNGS, its pan-cancer assay for solid tumors. The updated 500-gene assay sequences DNA and RNA from tumor samples to detect all clinically actionable biomarkers — including microsatellite instability, tumor mutational burden, and PD-L1 — recommended by leading guidelines, in a single test. Test results are provided in a streamlined report that facilitates interpretation and identification of potential treatment options and clinical trials, Strata said.

Mar 19, 2019

Mission Bio Tapestri Designer

Mission Bio has launched Tapestri Designer, a cloud-based tool for customers to design and order single-cell DNA panels. The tool makes use of artificial intelligence and machine learning to enable customers to order customized gene panels, reducing turnaround time for panel design to minutes from weeks, according to the company. Tapestri Designer allows researchers to complete custom designs in three steps: set up an account; upload a CSV file or enter a gene, ID, or coordinate targets; and submit a design to receive results.

Mar 18, 2019

Karolinska University Hospital Genetic Analysis Services

The Mutation Analysis Facility (MAF) at Karolinska University Hospital is launching a range of genetic analysis services targeting the European research and clinical market and focusing on areas such as cancer profiling for solid tumors and liquid biopsy, as well as pharmacogenetics. MAF has ISO/IEC 17025 accreditation for core methods by the Swedish SWEDAC authority, and will offer a broad portfolio of services including genome-wide analysis, targeted epigenetic analysis, and DNA methylation for precision medicine research and clinical decision making. Karolinska highlighted in particular its SNP genotyping expertise, noting that it uses MALDI-TOF analysis performed on Agena Bioscience's MassArray platform to simultaneously genotype several SNPs for both small- and large-scale applications.

Mar 14, 2019

Shield Diagnostics Target-NG

Shield Diagnostics, a CLIA-certified clinical laboratory based in San Jose, California, has launched Target-NG, a rapid molecular test for antibiotic susceptibility in Neisseria gonorrhoeae. The test, which users can run on urine, rectal, and pharyngeal samples, can determine if a given gonorrhea infection is susceptible to ciprofloxacin with the same turnaround time as standard gonorrhea screening tests, the company said.

Mar 12, 2019

Diagenode Megaruptor 3

Diagenode has launched Megaruptor 3, a new version of its DNA shearing instrument. The Megaruptor pumps DNA in solution through an array of uniform pores several times, stretching and breaking the DNA strands in the process. The device is designed to shear DNA into 5 kb to 100 kb fragments and can handle between one and eight samples per run.

Mar 12, 2019

Integrated DNA Technologies and Aldevron's GMP SpyFi Cas9 Nuclease

Aldevron and Integrated DNA Technologies have released GMP SpyFi Cas9 Nuclease for clinical and commercial applications. SpyFi Cas9 Nuclease, which is the trade name for Aldevron's research grade and GMP products, was developed through a partnership between the two companies. The advantages of SpyFi Cas9 Nuclease include reduced off-target effects combined with clinically relevant on-target activity, Aldevron said. Its release provides researchers and scientists with a consistent product for gene editing programs, from discovery through clinical and commercial manufacturing. 

This specific Cas9 protein variant resulted from a substantial amount of development of the wild-type Streptococcus pyogenes Cas9 sequence. This nuclease also functions well in ribonucleoprotein (RNP) delivery format and is compatible with ex vivo gene editing protocols. GMP-grade SpyFi Cas9 Nuclease is available in 1 mg and 10 mg vials.

Mar 12, 2019

Oxford Nanopore Technologies Flongle

Oxford Nanopore Technologies has launched Flongle ("flow cell dongle"), an adapter for the MinIon and GridIon X5 sequencing platforms that takes single-use flow cells. Each $90 Flongle flow cell contains 126 channels and currently produces up to 1.8 Gb of sequence data, an output that is expected to increase to more than 3 Gb in the future. The firm said it has designed the device for small-genome sequencing, panel sequencing, metagenomic sequencing to identify microbes or characterize microbiomes, and library quality control for larger nanopore sequencing experiments.

Mar 11, 2019

DNAnexus Clinico-Genomic Cohort Browser

DNAnexus has added a cohort browser to its DNAnexus Apollo platform for clinico-genomic data science exploration, analysis, and discovery. This represents the commercial launch of a browser that the Regeneron Genetics Center used to analyze a new set of 50,000 exomes and related phenotypes for the UK Biobank study.

Mar 11, 2019

23andMe Type 2 Diabetes Report

Consumer genetics company 23andMe on Sunday launched a Type 2 Diabetes Report that tells customers if they are at risk of developing the disease and the lifestyle changes that could make a positive difference. "The report can help customers learn how their genetics, along with other factors such as their weight, age and lifestyle, may influence the likelihood of developing type 2 diabetes, as well as actions they can take to lower that likelihood," 23andMe said in a blog post.

Unlike the company's other genetic health risk tests, which tell customers if they have specific disease-linked SNPs, the type 2 diabetes test employs a polygenic risk score (PRS) that combines more than 1,000 SNPs in an algorithm. This latest test has not been approved or cleared by the US Food and Drug Administration in contrast to the firm's earlier genetic health risk tests.

23andMe said it developed and validated the PRS using the real-world data of 2.5 million customers who have opted to donate their genetic and phenotypic information to research. In a white paper, the company notes that the type 2 diabetes PRS was developed on variants from genome-wide association studies involving people of European ancestry, and that it trained the score on Europeans and recalibrated for other populations. The data show that the score works best in those of European ancestry and doesn't work as well in African American populations.

Mar 07, 2019

LGC, Biosearch Technologies RapiDxFire Thermostable RT

LGC, Biosearch Technologies has launched RapidDxFire Thermostable RT, a thermostable reverse transcriptase designed specifically for diagnostic kit developers. The enzyme's optimum temperature of 55° C to 80° C improves reaction specificity and allows synthesis from diverse RNA templates. It also has a reaction time of five minutes or less, and is recommended for targets under 1 kb. Its extended stability at room temperature make it compatible with automation, and the enzyme is available in a lyophilization-ready Triton X-100-free format, the company said.

Mar 07, 2019

BioIVT Xpressway Profile Safety Package

BioIVT has launched the Xpressway Profile Safety Package, a compendium of 46 expression profiles for genes known to play pivotal roles in drug safety assessments. These genes are included in the initial screening panel used by pharmaceutical companies to evaluate new chemical entities for potential off-target interactions and toxic effects. Once these entities have been screened against the 46 target genes, the Xpressway Profile Safety Package allows the resulting binding data to be compared with the corresponding human target expression profiles and interpreted further to assess potential safety risk, the company said. When NCEs bind to the targets, the tissue distribution of those targets can inform decision making about the compounds and chemical series. BioIVT said that it employed a rigorous, highly controlled qRT-PCR method to develop the Xpressway Profile Safety Package's gene expression data.

Mar 06, 2019

IDT rhAmpSeq Targeted Sequencing System

Integrated DNA Technologies (IDT) has launched the rhAmpSeq targeted sequencing system. The proprietary rhAmpSeq chemistry enables highly multiplexed target amplification for sequencing on Illumina platforms with high on-target rates and uniform coverage. Its applications include human disease research, sample tracking and analysis, CRISPR genome editing analysis, and agricultural biotechnology. The system makes use of IDT's RNase H2 PCR technology, employing an RNase H2/DNA polymerase enzyme system coupled with RNA-DNA hybrid primers. It has been optimized for panel sizes from tens to thousands of amplicons in a single reaction.

Mar 06, 2019

Beckman Coulter Apostle Minimax High Efficiency Cell-Free DNA Isolation Kit

Beckman Coulter has launched the Apostle MiniMax High Efficiency Cell-Free DNA Isolation Kit through an exclusive partnership with liquid biopsy firm Apostle. The tool is a magnetic nanoparticle-based kit that extracts cfDNA from plasma using manual or automated workflows. According to the firm, the kit performs reliably across a range of volume inputs while consistently recovering high quantities of cfDNA and effectively removing contaminants. 

Mar 05, 2019

Loop Genomics mRNA Transcript Counting and Phasing

Loop Genomics has launched a kit and service for mRNA transcript counting and phasing using its synthetic long-read technology that works in conjunction with next-generation sequencing on Illumina instruments. The kit costs $70 per sample and the service $299 per sample. The San Jose, California-based startup, uses unique molecular identifiers and enzymes to attach the same barcode at multiple positions along one long molecule.

Mar 01, 2019

Twist Bioscience Target Enrichment Products

Twist Bioscience has launched several new products for its Twist Human Core Exome Kit and Twist Custom Panels NGS target enrichment workflows. The products include Twist Fast Hybridization and Wash Kit, Twist Universal Blockers that allow flexible blocking and improved on-target capture, the Twist Universal Adapter System that maximizes performance for library preparation, and the Twist Mechanical Fragmentation Library Prep Kit for highly-degraded samples. According to the firm, the products will accelerate hybridization to about 15 minutes and will seamlessly integrate into any automation workflow.

Mar 01, 2019

Lexogen Corall Whole Transcriptome Library Kit

Lexogen has launched its Corall Total RNA-Seq Library Prep Kit. The firm said that researchers can use the kit for all whole-transcriptome analysis applications, including differential expression, isoform quantification, and single nucleotide polymorphism and mutation detection. Lexogen highlighted that Corall can use as little as 1 nanogram and up to 1 microgram of total RNA. The kit integrates unique molecular identifiers that facilitate the identification and removal of PCR duplicates, while ensuring high strand specificity. The kits include up to 96 i7 indices for sample multiplexing. Researchers can also add i5 indices for a total of 9,216 indexing combinations. The firm offers the kits in in 24 and 96 prep sizes, as a standalone library preparation kit, or in combination with with the RiboCop rRNA Depletion Kit.

Mar 01, 2019

Furukawa Electric Single Cell Hunter

Furukawa Electric has launched the Single Cell Hunter, a microchip-based automated live cell high-throughput screening system. Single Cell Hunter analyzes live cells on a microchip within a temperature-adjustable chamber to catch the responses of stimulated cells under near-physiological conditions and identify them in a time-lapse mode, which enables accurate evaluation of the real potential of each cell. The system features standard, pre-coated microchips for dynamic identification and recovery of fluorescence-labeled cells, or for fluorescence-linked immunosorbent assays for the identification of the cells that have an ability to secrete antibodies or specific antigen proteins. The platform also features multi-color screening, and AI-based high-precision cell-friendly pick-up and drop-off technology, which enables recovery of even a single yeast cell as small as 3 μm in diameter from a 10-μm microwell.

Mar 01, 2019

Bionano Genomics Saphyr Chip, Sample Prep, Data Analysis

Bionano Genomics this week released new products related to its Saphyr platform for structural variation detection in genome analysis. First, the company launched a new version of the Saphyr Chip with three independent flowcells. When running on the two-chip Saphyr platform models that ship in 2019, the 3 X 1300 Saphyr Chip allows customers to map up to 42 whole human genomes per week or collect 1,300 Gbp (400x) coverage in less than 48 hours for samples in each of three flowcells.

The company also released a new kit for DNA isolation from blood and cells called Bionano Prep SP (solution phase). According to the company this kit dramatically reduces the time and effort needed to obtain extremely long, ultra-high molecular weight DNA by eliminating steps like plug-lysis and drop dialysis. Bionano Prep SP enables users to manually process up to six patient samples in less than three hours or up to 12 patient samples per day, which reflects a savings of a full day from the workflow compared to the current plug-lysis approach, Bionano said. The new kit also costs less on a per-sample basis, the protocol is automatable, and the high purity of resulting DNA enables faster run times on the instrument and higher data quality, the company noted.

Bionano also announced the upcoming release of the latest version of Bionano Solve, its suite of data-analysis tools, which for the first time will be available in a cloud-based implementation called Bionano Compute On-Demand. The pipeline analyzes single molecules for structural variation detection at low-allele fractions, and is particularly suited for analysis of complex, heterogeneous cancer samples and samples with germline mosaicism, the company said. All major types of structural variation can be detected with more than 80 percent sensitivity when present in just 5 percent allele fraction, while translocations and inversions can be detected with more than 90 percent sensitivity at this low frequency.

Feb 28, 2019

Agilent Magnis NGS Prep System

Agilent has launched the Magnis NGS Prep System, a fully automated next-generation sequencing library preparation system. The firm has designed the platform to help researchers easily assay multiple genes and complex genetic aberrations from genomic DNA, including degraded samples such as formalin-fixed, paraffin-embedded specimens, Agilent said. The system comes with pre-aliquoted reagents and pre-set protocols, and is fully compatible with Agilent's SureSelect [XT HS] library prep workflow. The system can provide reproducible results with a one-day turnaround time, Agilent noted.

Feb 27, 2019

Dolomite Bio scRNA-Seq Reagent Kit

Dolomite Bio has launched its new scRNA-Seq Reagent Kit, which the firm said will expand the Nadia instrument portfolio. Dolomite said it has designed the kit to allow reliable and robust generation of PCR-amplified cDNA libraries on its Nadia instrument, allowing researchers to achieve reproducible datasets at low sequencing costs. The firm said that the set up also allows users to adjust the number of single cell cDNA libraries prior to sequencing, which it believes will ensure cost-efficient single cell analysis.

Feb 22, 2019

Stratec Molecular InviMag FFPE DNA Kit

Stratec Molecular has launched its InviMag FFPE DNA kit, which the firm said allows efficient, fully automated purification of pure and PCR inhibitor-free DNA from formalin-fixed, paraffin-embedded tissue samples on its InviGenius PLUS platform. The instrument uses a robotic system for a magnetic bead-based isolation of nucleic acids from 12 samples in parallel. Stratec said the method reduces hands-on time, with only 15 minutes of preparation time for loading the instrument and protocol selection. The firm believes the kit will help increase productivity and efficiency to obtain reliable test results in molecular pathology analysis.

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