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Biognosys: P2 Plasma Enrichment, Spectronaut 19, True Target, Digital Proteome, Proteoverse

Biognosys this week introduced its P2 Plasma Enrichment offering which the company said allows for measurement of up to 7,000 proteins in plasma. According to the company the method provides excellent quantitation and high throughput for large-cohort biomarker or drug discovery studies as well as clinical, epidemiological, and population proteomics research. It is available as a service through Biognosys or as an in-house method end users can license and run.

The company also launched its Spectronaut 19 software package for data-independent acquisition mass spec analysis; its TrueTarget tool for high-throughput limited proteolysis mass spec experiments; its DigitalProteome database for use in in vivo biomarker discovery and drug development studies; and its Proteoverse data visualization platform.

Shimadzu: LCMS RX Triple Quadrupole Mass Spectrometry Series

Shimadzu this week introduced its new series of LCMS RX Triple Quadrupole Mass Spectrometry instruments. The series consists of the LCMS-8045RX system, intended for routine analysis; the LCMS-8050RX system, for higher sensitivity analyses; and the LCMS-8060RX, the company's flagship triple quad.

The systems feature the company's CoreSpray technology, which improves heat distribution of the ionization source, improving sample ionization, as well as its IonFocus electrode, which removes matrix contaminants, lowering noise levels and improving data quality. The systems' Performance Concierge feature proactively evaluates system performance with a standard solution, troubleshoots problems, and notifies operators of maintenance needs, effectively minimizing instrument downtime.

Qlucore Insights

Swedish company Qlucore has released a new version of Qlucore Insights, a bioinformatics model to classify primary lung tumor samples and metastatic lung cancer lesions that was developed in collaboration with Heidelberg University Hospital in Germany. The new model assigns a sample to one of 18 subgroups. It is based on RNA data from more than 300 FFPE samples and was developed using AI-based machine learning techniques.

NimaGen EasySeq Full-Length 16S Library Prep Kit

Dutch sequencing technology firm NimaGen has launched its EasySeq full-length 16S library prep kit to enable full 16S rRNA sequencing for microbiome deconvolution and bacterial species ID within eight hours. Powered by reverse complement PCR, the singleplex assay generates one amplicon that can be sequenced on all Oxford Nanopore Technologies platforms using any ligation sequence kit. Depending on the required read depth, up to 96 samples can be multiplexed, according to the company's website. The kit can be used to directly amplify DNA from environmental, food, human, or animal-derived samples without the need for culture, NimaGen said.

Dotmatics Geneious Cloud Workspace and Geneious Prime 2024

Boston-based scientific software firm Dotmatics has released Geneious Cloud Workspace and Geneious Prime 2024, both of which are designed to facilitate genomic data analysis and research.

Geneious Cloud Workspace enables scientists to collaborate across workstations and provides a unified view of their collective research data, the company said. The cloud-based software provides scalable and secure storage, enhances collaboration, and facilitates efficient data management across diverse data types and formats, Dotmatics added.

Geneious Prime 2024's features include a cloning validation tool and "Map to References" algorithm advisor, enhancing researchers' ability to quickly and precisely navigate complex genomic analyses, Dotmatics said.

Cytek Biosciences Enhanced Small Particle Detection for Cell Analysis Systems

Cytek Biosciences has introduced an Enhanced Small Particle (ESP) detection option for its flagship Cytek Aurora and Cytek Northern Lights cell analysis systems. This optional upgrade enables the company's systems to detect subcellular materials, including extracellular vesicles, with high resolution and sensitivity, the company said. Flow cytometers typically have been unable to detect particles smaller than 500 nm, the company noted, limiting their use to the study of cells and larger particles. Now, particles as small as 70 nm can be studied label-free on Cytek's Full Spectrum Profiling (FSP) analyzers, allowing researchers to characterize the full emission spectra of small particles.

Foundation Medicine FoundationOne RNA

Roche subsidiary Foundation Medicine has launched its FoundationOne RNA test for clinical use in the US. The tissue-based RNA sequencing test detects cancer-related fusions across 318 genes and enables reporting of fusions in all solid tumors. Foundation noted that the test may be valuable for detecting fusions in certain cancers, including non-small cell lung cancer, pancreatic cancer, cholangiocarcinoma, sarcoma, thyroid cancer, and bladder cancer. The company originally made the test available in September 2023 for research and investigational use. FoundationOne RNA can now be added to FoundationOne CDx orders for even greater confidence in fusion detection, the company noted.

Micronbrane Medical PaRTI-Cular mNGS Bioinformatic Web App

Micronbrane Medical launched the PaRTI-Cular Bioinformatics Web Application for research use only (RUO). The cloud-based, code-free tool is complimentary when used with the company's Pathogen Real-Time Identification by Sequencing (PaRTI-Seq) assay. PaRTI-Cular is a curated, continually updated pipeline with genome information for thousands of microorganisms including bacteria, viruses, fungi, and parasites. The RUO version applies preset parameters developed by Micronbrane Medical and has been rigorously tested with numerous low biomass human clinical samples, the company said. Downloadable data includes counts and percentages of raw, QC, control, human, microbial, and unclassified reads by species, the company added.

Bosch Healthcare Solutions Vivalytic Candida Auris Assay

Bosch Healthcare Solutions has launched a PCR test for detecting Candida auris on the Vivalytic platform. The system can provide fully automated detection of the fungus in less than one hour at the point of care, and can be used for diagnosis or screening. The Vivalytic C. auris test is now available from distribution partners, including Randox Laboratories and R-Biopharm, and Bosch Healthcare Solutions is in the process of obtaining CE certification.

Twist Bioscience Multiplexed Gene Fragments

Twist Bioscience has launched its Multiplexed Gene Fragments, pools of directly synthesized double-stranded DNA between 301 bp and 500 bp long to enable high-throughput screening applications. 

The fragments are synthesized from customer-defined sequences with no limit on sequence number, though pool size starts at 1,000. Turnaround time is eight business days. 

Potential applications include CRISPR-based screening and genome engineering, antibody discovery, protein engineering applications, mRNA vaccine development, and massively parallel reporter assays, the company said.