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Nov 14, 2019

Loop Genomics Long-Read PCR Amplicon Sequencing Kit, Service

Loop Genomics has launched a new amplicon library prep kit and service for generating synthetic long sequence reads from long PCR amplicons on Illumina sequencers. The kit can be used for PCR fragments up to 3 kb in size and the service can process orders for PCR fragments up to 6 kb long.

Nov 14, 2019

Grifols AlphaID,

Grifols has lunched the AlphaID, a cheek swab for use by doctors to screen patients with chronic obstructive pulmonary disease for alpha-1 antitrypsin deficiency, or Alpha-1, a rare, life-threatening genetic condition. Grifols said the swab is free "from ordering to results" and leverages a US Food and Drug Administration-approved genotyping assay to screen for the 14 most prevalently reported genetic mutations associated with Alpha-1, including the S, Z,F, and I alleles, as well as rare and null alleles. 

Nov 13, 2019

Personalis Whole Genome Sequencing Service

Personalis has launched a new whole genome sequencing service, extending its existing portfolio of comprehensive cancer 'omics tests, including targeted gene panels, exome, and transcriptome products. The company said that the new offering reflects its experience analyzing cancer samples across numerous biopharma oncology clinical trials, and takes advantage of "large-scale laboratory and data systems" developed as part of its WGS effort for the US Department of Veterans Affairs' Million Veteran Program.

Nov 08, 2019

Akoya Biosciences Motif PD-1/PD-L1 Panels

Akoya Biosciences has launched two multiplex immunofluorescence kits for profiling immuno-oncology biomarkers in the tumor microenvironment. The Motif PD-1/PD-L1 panels focus on PD-1 immune checkpoint blockade in lung cancer and melanoma. Each kit includes six immunofluorescence markers, plus nuclear counterstain, to capture the cellular interactions associated with PD-1/PD-L1 immune suppression. The kits are optimized for high-throughput staining on commonly used autostainers and rapid scanning on the Vectra Polaris multiplexed imaging system.

Nov 07, 2019

Ceres Nanosciences Nanotrap Virus Capture Kit

Ceres Nanosciences has launched the Nanotrap Virus Capture Kit, which concentrates whole virus particles from complex biological matrices resulting in high-quality input material for a range of downstream analytical methods such as multiplex nucleic acid, protein, and infectivity assays. The company said that it has data demonstrating the kit's compatibility with multiple commercial nucleic acid kits for influenza virus samples, as well as an application note demonstrating use of the technology to improve the detection of Zika virus in urine samples.

Nov 07, 2019

Ultivue UltiMapper Multiplex Immunofluorescence Kits

Ultivue has expanded its UltiMapper Multiplex Immunofluorescence Kit portfolio with a T-reg and MDSC kit. The UltiMapper I/O T-reg kit identifies regulatory T cells and cytotoxic T cells within the tumor context and allows for the phenotyping of activated double-positive T cells. The UltiMapper I/O MDSC kit enables the identification and characterization of myeloid-derived suppressor cells and allows researchers to differentiate M-MDSC from PMN-MDSC phenotypes. The new kits feature high-throughput whole-slide imaging using the same conventional IHC equipment and workflows as the previously released UltiMapper I/O PD-L1, UltiMapper I/O PD-1, UltiMapper I/O T-act, and UltiMapper I/O APC kits, the company said.

Nov 07, 2019

Qiagen QiaSeq Multimodal Panels

Qiagen has launched a new workflow, called QiaSeq Multimodal Panels, for the simultaneous preparation of DNA and RNA libraries for next-generation sequencing. The panels require an input as low as 10 nanograms of total nucleic acid and the workflow takes about nine hours. Both libraries are generated from the same sample and allow for the analysis of DNA variants, RNA fusions, and gene expression levels.

Nov 07, 2019

Lifebit Biotech CloudOS

Lifebit Biotech has introduced Lifebit CloudOS, a clorud-native, federated genomics operating system that supersedes the beta-release Lifebit Deploit from 2017. CloudOS works as a managed service of individual clouds or high-performance computing centers to support analysis of bioinformatics data across sites and institutions. The company said that this system automates analysis and the application of machine learning, removing a major barrier to precision medicine, population, genomics, drug discovery, and direct-to-consumer genetics progress. 

Nov 06, 2019

Genomenon Mastermind 2.0

Genomenon has introduced version 2.0 of its Mastermind genomic search engine. The new release features the ability to search genomic literature by phenotype to help with the diagnosis of rare and hereditary diseases. Genomenon said that this addition was the most requested improvement to the product from children's hospitals and genetic testing laboratories alike. 

Nov 05, 2019

Agena Bioscience VeriDose CYP2D6 CNV Panel

Agena Bioscience has launched the VeriDose CYP2D6 CNV panel to provide PGx testing programs with a more accurate and efficient way to analyze CYP2D6 copy number. The research-use-only panel quantifies CYP2D6 copy number even in the presence of CYP2D6/CYP2D7 hybrid alleles, which cannot be detected by commonly used PGx technologies, the company said. The panel can also be run alongside Agena's PGX genotyping panels.

Nov 05, 2019

Paragon Genomics CleanPlex CFTR Panel

Paragon Genomics this week introduced the CleanPlex CFTR Panel for cystic fibrosis testing. The panel uses the company's CleanPlex target enrichment technology for a multiplex PCR-based targeted sequencing assay to evaluate somatic and germline variants in the CFTR gene. It covers all exons of the gene and includes mutations recommended by the American College of Medical Genetics and Genomics.

Nov 05, 2019

Loop Genomics: Long Read Microbiome Sequencing Service

Loop Genomics has launched a new service for linked read microbiome sequencing for studies with large cohorts. For labs running at least 200 to 1,000 samples, Loop is offering 16S sequencing at a price between $38 and $20 per sample, depending on volume. Loop generates long reads using Illumina's short-read sequencing platform. The firm said it can deliver 40-fold lower error rates and can eliminate false positives, delivering species- and sometimes strain- level taxonomy.

Nov 01, 2019

Genome Medical's Genome Care Delivery

Genome Medical, a telegenomics technology and services company, has launched Genome Care Delivery, a cloud-based platform that provides hospitals, health systems, and employers virtual access to a nationwide network of clinical genetics specialists in order to expedite and facilitate the delivery of genetic expertise. The platform is initially focused on oncology and reproductive health, and is intended to deliver education, engagement, and access to genetic experts for virtual visits and provider-to-provider consults, as well as genetic wellness assessment and screening for population health management, the company said. Features include curated content, adaptive videos, webinars, online assessment tools, virtual care visits with genetic specialists, personalized recommendations regarding genetic testing, and clinical action plans based on genetic test results and medical management guidelines.

Oct 31, 2019

SeraCare SeraSeq TMB gDNA and FFPE Reference Materials

SeraCare Life Sciences has released what it says are the first available genomic DNA and formalin-fixed paraffin-embedded reference materials for tumor mutational burden measurement by next-generation sequencing assays. The company created the new materials as part of its work with the Friends of Cancer Research TMB harmonization working group and the International Quality Network for Pathology's TMB EQA Pilot Program.

Data generated from using the reference samples was presented by FOCR at the 2019 American Society of Clinical Oncology Meeting, and by IQN Path at the 2019 European Congress of Pathology, demonstrating their utility in harmonizing and standardizing measurements of TMB by different NGS assays.

In addition to the new SeraSeq TMB gDNA and FFPE materials available now, SeraCare said it can also create custom tissue and blood-based TMB reference materials through its VariantFlex custom reference material development platform.

Oct 31, 2019

Becton Dickinson Rhapsody Whole-Transcriptome Analysis Amplification Kit

Becton Dickinson has released a new solution for combined whole-transcriptome and protein analysis in single cells.

The BD Rhapsody Whole Transcriptome Analysis Amplification Kit enables unbiased 3'-based capture, amplification, and detection and is designed to work with BD's Rhapsody single-cell analysis system and AbSeq reagents. It is also optimized to work with BD's Single-Cell Multiplexing kit to improve efficiency.

The research-use-only kit is validated for use with a wide range of cell inputs.

Oct 31, 2019

Thermo Fisher Scientific Oncomine Comprehensive Assay Plus

Thermo Fisher Scientific has launched the Oncomine Comprehensive Assay Plus for the detection of targeted and immuno-oncology biomarkers. The assay, designed for solid tumors, covers more than 500 genes and enables analysis of both DNA and RNA in a single workflow. It detects single nucleotide variants, indels, copy number variants, gene fusions, and splice variants and is suitable for microsatellite instability (MSI) and tumor mutational burden (TMB) assessment. The assay requires 1 ng DNA/RNA input and fits seamlessly into existing Thermo Fisher Ion Chef and Ion GeneStudio system workflows.

Oct 31, 2019

Yourgene Flex Analysis Software

Yourgene of Manchester, UK, has launched the Yourgene Flex Analysis Software to support the company's plans to develop next-generation sequencing-based in vitro diagnostic products with partners and research collaborators in industry. The software platform builds on the company's Iona software and will also be deployed internally to support Yourgene's internal product development pipeline in reproductive health and oncology. Its components allow for sequence data to be read, filtered, and analyzed, and to generate bespoke clinical test reports. All elements of the software are developed to standard ISO/IEC 62304, which supports in vitro diagnostic regulatory submissions.

Oct 30, 2019

RareCyte Prostate Cancer RarePlex Staining Kit

RareCyte has launched a new RarePlex Staining Kit for evaluating prostate cancer specific expression of ARv7 on circulating tumor cells. When combined with the firm's CTC analysis platform, the RarePlex ARv7 CTC Panel kit allows researchers to perform first blood-to-result prostate-specific CTC assay in their laboratories. RareCyte said the kit contains CTC detection markers in addition to ARv7 and can be performed on an automated slide staining system. 

Oct 30, 2019

ATCC Cell-Specific Exosomes

ATCC has launched a portfolio of human-derived exosomes to serve as reference materials or standards for a variety of research applications. The firm's first two exosomes available are dervied from the A549 non-small cell lung cancer (NSCLC) cell line and hTERT-immortalized mesenchymal stem cells. 

Oct 29, 2019

DxTerity Diagnostics IFN-1 Test

DxTerity Diagnostics has launched the IFN-1 Test for determining a systemic lupus erythematosus patient's type 1 interferon status and the risk of progressing to lupus nephritis. The firm launched the test after releasing results of a longitudinal clinical study with the Oklahoma Medical Research Foundation, to be presented on Nov. 11 at the American College of Rheumatology annual meeting in Atlanta. The test, DxTerity said, is currently being used to select and monitor patients for SLE clinical trials. While therapies targeting IFN-1 have shown promise in Phase II clinical studies, they have had disappointing results in Phase III randomized trials. The ability to select patients who overexpress IFN-1, based on RNA profiling, is seen as crucial for the future success of clinical trials, DxTerity said. The IFN-1 assay a gene expression module contained within the company's Modular Immune Profile assay, which was developed to measure the relative gene expression of immune system-related genes.

Oct 29, 2019

New England Biolabs NEBNext RNA Depletion Kits

New England Biolabs has launched two new RNA depletion products to support next-generation RNA sequencing.

The NEBNext Globin & rRNA Depletion Kit (human/mouse/rat) depletes adult, fetal, and embryonic globin mRNA (HBA1/2, HBB, HBD, HBM, HBG1/2, HBE1, HBQ1 and HBZ), as well as cytoplasmic rRNA (5S, 5.8S, 18S, 28S, ITS and ETS) and mitochondrial rRNA (12S and 16S).

The NEBNext rRNA Depletion Kit (bacteria) removes the abundant bacterial rRNAs (5S, 16S, and 23S) resulting in the enrichment of bacterial mRNAs and non-coding RNAs of interest. This method is targeted to both gram-positive and gram-negative organisms, and is effective with RNA from monocultures or mixed bacterial species, such as those used in metatranscriptome studies, NEB said.

The new kits complement the NEBNext products for RNA library preparation, including the Ultra II Directional RNA Library Prep Kit for Illumina and the NEBNext Library Quant Kit for Illumina, as well as the Monarch Total RNA Miniprep Kit, the company said.

Oct 25, 2019

NYU Langone Health Perlmutter Cancer Center Clinical Whole-Genome DNA Methylation Profiling for Brain Tumors

NYU Langone Health's Perlmutter Cancer Center has launched clinical whole-genome DNA methylation profiling for patients with brain tumors. This molecular assay utilizes DNA epigenetic signatures and artificial intelligence with machine learning to identify and subtype brain tumors.

The test received New York State Department of Health approval on April 3.  

Oct 25, 2019

Biocartis Idylla ctEGFR Mutation Assay

Biocartis has globally launched its Idylla ctEGFR Mutation Assay. The firm noted that the research-use-only tool is the liquid biopsy version of its solid biopsy Idylla EGFR Mutation Test. Running on the Idylla platform, the assay allows users to detect 49 EGFR mutations directly from 2 ml of blood plasma and provides resutls within 160 minutes, Biocartis said.

Oct 23, 2019

Synthego High-Throughput Induced Pluripotent Stem Cell Genome Engineering

Synthego has launched a genome engineering service for induced pluripotent stem (iPS) cells. The new offering expands on Synthego's automated cell editing technology to achieve high editing efficiency of iPS cells at an industrial scale. Synthego said its cell-editing platform makes editing, cloning, and maintaining high pluripotency in clinically relevant iPS cells easier, with editing rates as high as 90 percent prior to cloning and 100 percent in clones. The new offering of iPS cells includes modifications by gene knockout, single-nucleotide variation, protein tagging, and other knock-ins.

Oct 20, 2019

Sophia Genetics Whole Exome Solution

Sophia Genetics has released a new version of Sophia Whole Exome Solution, which the company said reduces turnaround time for analysis of whole-exome sequences. The updated Sophia WES now features detection of copy-number variations at a resolution of two to five exons without the need for a reference sample. The product also supports analysis of variants in familial trios to filter variants based on different inheritance modes. 

Pages

The Centers for Disease Control and Prevention estimates more people get sick and die from drug-resistant germs than previously thought, the Washington Post reports.

According to the Associated Press, three universities and a healthcare institution are sharing a gift of $1 billion.

New rules seek to limit the type of scientific and medical research that can be used to guide public health regulations, the New York Times reports.

In Nature this week: FreeHi-C approach simulates Hi-C data from interacting genome fragments, and more.