In Vivo Senior Scientist, Oncology

AstraZeneca Pharmaceuticals
Job Location
Waltham, MA
Job Description

Seeking a highly motivated in vivo cancer pharmacologist with industry experience to join the In Vivo Oncology team at AstraZeneca, Waltham MA. Primary focus will be the design and execution of in vivo studies to advance new drug candidates in the Oncology portfolio. This will include developing and characterizing mouse models of cancer, design and delivery of in vivo PK/PD screening cascades to support lead optimization, in vivo efficacy studies to support dose and schedule optimization and hypothesis driven combinations.


•Ph.D. with 2+ years or BS/MS with 5+ years industry experience in cancer pharmacology required, with focus on in vivo studies to advance cancer drug candidates 
•Experience using mouse models of cancer (xenograft, primary patient, and syngeneic) to evaluate the in vivo pharmacology of small molecule drugs. 
•Experience and strong working knowledge of in vivo pharmacology techniques required, including preparation of test compounds, handling and dosing mice, and collection of blood and tissues for PK and PD biomarker analysis. 
•Experience with sterile tissue culture, and with basic cellular biology techniques required 
•Experience with preclinical development of immune modulating agents for cancer is desired. 
•Demonstrated ability to interface with project teams on preclinical stage projects required 
•Strong track record of delivery of high quality in vivo data. 
•Strong communication skills. 
Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled/Sexual Orientation/Gender Identity Location MA, Waltham Category Research and Non-Clinical Development Date Posted 6/22/2015 Req Number 14-50063484 Notice AstraZeneca does not accept non-solicited resumes or candidate submittals from search/recruiting agencies not already on AstraZeneca's approved agency list. Unsolicited resumes or candidate information submitted to AstraZeneca by search/recruiting agencies not already on AstraZeneca's approved agency list, and who were not asked to work on a specific vacancy, shall become the property of AstraZeneca and if the candidate is subsequently hired by AstraZeneca, AstraZeneca shall not owe any fee to the submitting agency. AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of cardiovascular, metabolic, respiratory, inflammation, autoimmune, oncology, infection and neuroscience diseases. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. For more information please visit AstraZeneca 
Making a Difference 
AstraZeneca is an equal opportunity employer

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