Variation Interpretation Scientist

Job Location
San Francisco, CA,
Job Description

Job Description


AncestryDNA is seeking a motivated, collaborative and talented scientist with experience interpreting the biological significance of genetic variation in diverse populations. Working with a nimble team of geneticists, statisticians, computational biologists, and epidemiologists, the Variation Interpretation Scientist will identify & summarize the scientific literature supporting the biological impact of these variants.




  • The successful candidate for the position will have an M.D. or Ph.D. in Genetic Epidemiology, Genetics, Statistics (or a related field).  
  • Experience with variant annotation or classification methods 
  • Experience assessing functional or medical significance of variants using scientific literature
  • Familiarity with statistical analyses and study design related to genotype-phenotype associations
  • Excellent verbal and written communication skills are essential
  • Strong organizational, time management, problem solving, and interpersonal skills will be needed in our fast-paced team
  • Familiarity with public databases (such as ExAc, ClinGen, ClinVar, and dbSNP)
  • Working knowledge in one or more of python, Java, C/C++ or R 
About Our Organization

Company Description


Ancestry is the largest provider of family history and personal DNA testing, harnessing a powerful combination of information, science and technology to help people discover their family history and stories that were never possible before. Ancestry’s suite of products include: AncestryDNA, AncestryHealth, AncestryProGenealogists, Fold3,, Find a Grave,, and Rootsweb.

AncestryDNA, is the world's largest consumer genomics database providing consumers insights into their ancestral origins. The service enables customers to not only uncover their ethnic mix and rich family stories, but discover distant relatives with a common ancestral match, and help solve the toughest family mysteries.

AncestryHealth, launched in 2015, empowers individuals to compile their family health history information to take charge of their health with tools to trace health conditions along family lines and understand what it means to individuals and their family while preserving this valuable information to share with their physicians and future generations.

  • AncestryHealth recently announced a collaboration with Calico, an Alphabet-funded biotech firm focused on longevity research and therapeutics, to investigate the heredity of aging/lifespan in diverse human populations. 

Ancestry by the numbers:

  • Since 1996, more than 16 billion records have been added, and users have created more than 70 million family trees on the Ancestry flagship site and its affiliated international websites. 
  • More than 1.2 million people genotyped in the AncestryDNA database.
  • Ancestry revenues have increased from $225M in 2009 to $620M in 2014.

The company has more than 1,300 employees in locations across the globe. Headquartered in Utah, Ancestry has offices in San Francisco, Dublin, London, Sydney, Munich, and Stockholm.

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