A postdoctoral position is currently available, in the laboratory of Dr. Christopher R. Vakoc, for a highly motivated outstanding individual to study the role of epigenetics in the pathogenesis of cancer. Over the last several years, chromatin-modifying enzymes have emerged as exciting therapeutic targets in oncology, however we understand very little about the epigenetic basis of cancer as a disease. Our laboratory has pioneered the use of functional genomics for the study of epigenetic vulnerabilities in cancer, which has led to the discovery of BRD4 as a leukemia drug target. The proposed studies will build upon these findings to discover novel therapeutic targets, using CRISPR-based genetic screens applied to animal models of cancer. This knowledge will lead to new drug-targeting opportunities and lead to basic research of transcriptional regulatory mechanisms that drive cancer progression. Experience in mammalian tissue culturing, genomic analysis, molecular biology, and mouse models is a plus.
Cold Spring Harbor Laboratory provides a highly dynamic and interactive environment for scientific research. In addition, our Meetings and Courses program provides an opportunity for interacting with a broad range of researchers and exposure to timely advances in many areas of scientific research.