to study the role of epigenetics in the pathogenesis of cancer

Cold Spring Harbor Laboratory
Job Location
Cold Spring Harbor, NY 11724
Job Description


A postdoctoral position is currently available, in the laboratory of Dr. Christopher R. Vakoc, for a highly motivated outstanding individual to study the role of epigenetics in the pathogenesis of cancer. Over the last several years, chromatin-modifying enzymes have emerged as exciting therapeutic targets in oncology, however we understand very little about the epigenetic basis of cancer as a disease. Our laboratory has pioneered the use of functional genomics for the study of epigenetic vulnerabilities in cancer, which has led to the discovery of BRD4 as a leukemia drug target. The proposed studies will build upon these findings to discover novel therapeutic targets, using CRISPR-based genetic screens applied to animal models of cancer. This knowledge will lead to new drug-targeting opportunities and lead to basic research of transcriptional regulatory mechanisms that drive cancer progression. Experience in mammalian tissue culturing, genomic analysis, molecular biology, and mouse models is a plus.


Cold Spring Harbor Laboratory provides a highly dynamic and interactive environment for scientific research. In addition, our Meetings and Courses program provides an opportunity for interacting with a broad range of researchers and exposure to timely advances in many areas of scientific research.



Interested individuals must be within ONE year of receiving or having received their Ph.D. Experience in mammalian cell culture, genomic analysis, molecular biology, and mouse models is a plus.


To be considered for this position candidates are required to apply via the CSHL website at


Position number 01152-R


For more information about CSHL, please visit us at


CSHL is an EO/AA Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability or protected veteran status.

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How to Apply

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