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Staff Scientist/ Lead Analytical Chemist

Organization
Inscripta
Job Location
5500 Central Ave.
#220
Boulder, CO 80301
United States
Benefits

Inscripta offers a competitive base salary, bonus plan, benefits package and stock options to all team members.  Join us and work with a great team of people developing the world's first scalable platform for benchtop Digital Genome Engineering. Inscripta is headquartered in Boulder, CO with offices in Pleasanton and San Diego, CA.  This position is located in our Boulder headquarters.

Job Description

Inscripta is developing the world's first scalable platform for benchtop Digital Genome Engineering. The company’s advanced CRISPR-based platform, consisting of an instrument, reagents, and software, will offer a fully automated workflow that enables multiplexed, trackable editing of cells at an unprecedented scale. Inscripta’s goal is to empower scientists whose gene editing research is stifled by current technical and licensing limitations. By providing this unique platform and engaging in collaborative business practices, such as making its MAD7 CRISPR nuclease free for research purposes, the company enables scientists to realize a new era of biological discovery.  

Inscripta is searching for a highly talented Staff Scientist/Lead Analytical Chemist to bring technical leadership and analytical chemistry expertise to a team building high-throughput, automated, genome engineering technologies. The ideal candidate will help drive new product development through leadership and innovation in analytical methodologies for chemistry and biomaterials development, genomic and transcriptomic characterization assay development, product and process performance testing and optimization, and hardware/consumable characterization.

Responsibilities include:

  • Lead innovation and development of analytical methodologies to enable new product and process development.
  • Evaluate and apply new characterization tools and quantitative assays using a variety of spectroscopic and/or analytical methods for biological, chemical and physical characterization of reagents and consumables.
  • Work closely with hardware and system integration engineers to develop measurement methodologies and controls to assess performance of automated instrumentation and consumables.  
  • Teach and establish a culture of strong experimental design practices, including sound measurement and control practices.
  • Manage external development partners and contact manufacturers; Interface with third party analytical labs to plan experiments and analyze results.
  • Perform Gauge R&R, verification, validation & transfer of tools and processes from R&D to manufacturing. 
  • Work collaboratively with biochemists, cell and molecular biologists, enzymologists, engineers (hardware and software), and bioinformaticians. 
  • Present clear and concise written and oral communications to colleagues and supervisors, lead and/or participate in technical meetings, and provide recommendations based on technical results.
Requirements

Required Educational Background and Work Experience:

  • PhD in Chemistry, Physical Chemistry, Biophysics, Biochemistry, or a closely related field.  
  • Must have at least 6 years non-academic work experience; experience in genomics, life sciences and/or molecular diagnostics strongly preferred.

Required Skills and Experience:

  • Demonstrated experience solving challenging, interdisciplinary research/development problems at the interface of biology, chemistry and materials science.  
  • Knowledge of techniques used for nucleic acid and protein analysis.
  • Strong theoretical and practical analytical chemistry skills.
  • Chromatographic techniques such as GC-MS and HPLC, Fluorescence microscopy, and spectroscopic methods are a plus.
  • Biophysics research in the behavior and interaction of DNA, proteins and/or other biological systems.   
  • Strong quantitative, applied mathematics experience in probability theory, multivariate calculus, differential equations, and advanced topics in analytical chemistry.  
  • Experience in at least one programming or scripting language such as R, Python, Matlab.  
  • Demonstrated ability to overcome technical challenges in a fast-paced environment within an interdisciplinary team setting.
About Our Organization

Inscripta is a gene editing technology company dedicated to creating the tools needed to revolutionize how we feed, fuel, and heal humanity. This includes developing a family of CRISPR enzymes (called MADzymes), bespoke nucleases for researchers and commercial partners, and a full suite of gene editing tools (software, instruments, and reagents) that will significantly increase the speed and efficiency of precision gene editing.

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