Staff Scientist, Functional Genomics

New York Genome Center
Job Location
New York, NY 10013
Job Description

About the Center for Genomics of Neurodegenerative Disease

The Center for Genomics of Neurodegenerative Disease (CGND) is dedicated to the study of neurodegenerative diseases such as ALS and Alzheimer’s disease. CGND’s vision is to establish a center for applying state of the art genetics, genomics and bioinformatics to the study of neurodegenerative disease mechanisms.  

Position Description

The CGND is looking for a highly self-motivated Staff Scientist with broad experience in both, molecular and computational methods related to the study of gene expression regulation. This is an exciting opportunity with significant potential for individual growth. The Staff Scientist will drive CGND’s diverse projects in the field of functional genomics. In this role, the Staff Scientist will develop and incorporate cutting-edge molecular and biochemical protocols (such as UV-CLIP, ChIP-seq and ATAC-seq) and apply and expand bioinformatics pipelines for the analysis and interpretation of next-generation sequencing data. The Staff Scientist will help to co-ordinate the efforts of on-site and off-site technical support staff, and provide expertise in his/her area of work to other team members and as part of external collaborations. The Staff Scientist will be part of a multi-disciplinary team, where enthusiasm and facility for learning new skills and applications will be necessary.

Job responsibilities will include:

  • Establishment and optimization of complex molecular and biochemical protocols for the generation of diverse genome-wide datasets from cell lines and tissues (such as UV-CLIP, ChIP-seq, ATAC-seq);
  • Perform advanced analysis and biological interpretation of genomics data sets from diverse in-house sources and external research collaborations;
  • Facilitate the planning and co-ordination of research programs involving in vitro cell differentiation and mouse models of ALS;
  • Provide expertise in Illumina-based NGS technology and data analysis;
  • Supervise technical support staff in the front-to-end NGS library preparation and quality control;
  • Train technical support staff in the execution of project-relevant tasks and protocols;
  • Stay up to date with advances and novel methods in biotechnology, sequencing technologies and bioinformatics tools to identify relevant developments and facilitate their on-boarding into CGND’s operations;
  • Write reports and present results to CGND’s leadership.
  • Ph.D. in Molecular Biology or related discipline, plus a minimum of 2 years relevant post-doctoral experience in both wet lab and computational biology;
  • Demonstrated ability to develop, apply and trouble-shoot complex biochemical protocols (e.g. ChIP, IP/co-IP, UV-CLIP);
  • Demonstrated knowledge of computational pipelines and tools for the analysis and interpretation of genomics data (e.g. RNA-seq, ribosome profiling, ChIP-seq, ATAC-seq);
  • Knowledge of two or more relevant programming languages (e.g. Unix shell scripting, Python, R, Perl);
  • Knowledge of relevant NGS tools (e.g. STAR, BWA, Bowtie, DESeq2, GATK, Samtools);
  • Knowledge of DNA and RNA biology and related protocols (including molecular cloning, RACE, PCR, qRT-PCR);
  • Ability to collaborate and communicate effectively with scientists in related disciplines, including external academic and industry collaborators;
  • Ability to multi-task while ensuring to meet deadlines;
  • Independence and a high degree of flexibility will be beneficial in a novel and rapidly changing research environment;
  • Experience with library preparation protocols for NGS highly advantageous;
  • Experience with neuronal, ESC and iPS cell culture is a bonus;
  • Experience supervising graduate, post-graduate or technical support staff is a bonus.
How to Apply

To apply, visit

About Our Organization

The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research. 

The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

NIH's Michael Lauer looks at the number of grants, their amount, and funding success rates at the agency for last year.

At Nature, Johns Hopkins' Gundula Bosch describes her graduate program that aims to get doctoral students thinking about the big picture.

Patricia Fara writes about childcare funding, and women in science and science history at NPR.

National Institute of Environmental Health Sciences researchers have visualized the career paths of former postdocs.