Staff Scientist, Clinical Laboratory

Organization
New York Genome Center
Job Location
101 Avenue of the Americas
New York, NY 10013
Job Description

The New York Genome Center Clinical Laboratory is looking for a Staff Scientist to assist with clinical data analysis and reporting for constitutional genomic assays.

Essential responsibilities include, but are not limited to

  • Identify, annotate and investigate the clinical significance of variants found in NGS-based clinical tests for constitutional disorders;
  • Prepare variant assessment summary, classify variants as per ACMG criteria, maintain accurate and detailed records of variant classification;
  • Use information from clinical notes to create a list of genes for inclusion or exclusion list for variant filtering and prioritizing;
  • Assist with literature review and interpretation of sequencing data;
  • Review Sanger sequencing and qPCR results and prepare variant level summary for clinical reporting;
  • Evaluate and implement tools for reporting and tracking variants assessed for clinical significance;
  • Assist in creation of precision medicine knowledge base of variant-disease associations in the context of constitutional disorders;
  • Prepare presentations for clinical case reviews and present evidence for multi-disciplinary review meetings; and
  • Participate in new assay validations and translational clinical activities as assigned.
Requirements
    • PhD in molecular biology, human genetics, biochemistry, or a related field required, MD desirable;
    • Knowledge of germline genomic variations (SNV, insertion, deletion, CNV, SV) in context of human germline disorders;
    • Search, extract, apply judgement and assess variant/disease specific information available from commonly used literature and genomics datasets;
    • Strong knowledge of Molecular Biology and Genetics;
    • Excellent written and verbal communication skills;
    • Excellent general laboratory and organizational skills, including the ability to work independently with minimal supervision and to train others in laboratory methods;
    • Thrives in a fast-paced, rapidly changing, start-up like environment; and
    • Self-motivated and capable of analyzing and solving complex problems through innovative thought and experience.


    Preferred

    • Prior experience working in a high volume clinical laboratory;
    • Experience with variant classification as per ACMG guidelines;
    • Previous NGS laboratory wet bench experience;
    • Knowledge of phenotype ontologies; and
    • Experience of working in a Linux environment, experience with SGE.
How to Apply

To apply, please visit http://www.nygenome.org/careers

About Our Organization

The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research. 

The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, creed, color, gender, religion, national origin, sexual orientation, age, disability, genetic predisposition or carrier status, protected veteran or military status, domestic violence victim status, partnership status, caregiver status, alienage or citizenship status, marital status, or any other characteristic protected by applicable law. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

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