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Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch's five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children's, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest.
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A laboratory studying protein kinases and ubiquitin ligases is seeking a motivated scientist to drive projects to dissect the roles of protein phosphorylation and ubiquitination in cell migration, proliferation and transformation.
The position is in a small basic science laboratory comprised of two postdocs, two graduate students and two technicians.
The staff scientist will:
1. Assist the principal investigator in supervising and mentoring lab members, providing feedback on experimental approaches and results (25%).
2. Perform independent research on sponsored projects, focused on the cell and molecular biology of posttranslational modifications by phosphotyrosine and ubiquitin (75%).
The staff scientist will independently identify and apply appropriate methods, develop and document procedures, and write detailed reports of results that are suitable for publications and grant applications.
- Design, perform and interpret experiments using standard cell and molecular biology techniques including cell culture, nucleic acid extraction and qRT-PCR, cloning, Western analysis, immunoprecipitation, and immunofluorescence.
- Perform routine analysis of data and assist with troubleshooting and daily quality control of data.
- Keep detailed records of procedures performed.
- Provide status reports to the principal investigator.
- Assist in training, supervising and mentoring other lab members.
- Contribute to basic lab maintenance, including ordering and helping with chemical safety paperwork.
- Participate in lab and inter-lab meetings as well as public presentations.
- Perform related duties as required.
- A doctoral degree or equivalent in a related field, and sufficient postdoctoral training to provide evidence of independent research ability.
- A record of publications in peer-reviewed journals that indicate an ability to conduct independent research and to bring projects to completion.
- Experience working in a research environment in a supervisory capacity.
- Experience in trouble-shooting standard techniques of cell and molecular biology, including molecular cloning, protein gels and westerns, cell culture, immunofluorescence, and live cell imaging. Applicants should either be experienced in these areas or have demonstrated a capacity to learn new techniques.
- Excellent communication, computer, documentation and project management skills.
General expectation of schedule is Monday-Friday, 9am to 5:30pm but requires working outside of the standard work week as needed. Salary is commensurate with education and experience.
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