Sr Staff Scientist\Sr Mgr Assoc Dir Clinical Geneticist\Mendelian | GenomeWeb

Sr Staff Scientist\Sr Mgr Assoc Dir Clinical Geneticist\Mendelian

Job Location
Job Description

Job Summary and Essential Functions:
The Regeneron Genetics Center is a wholly-owned subsidiary of the Company organized to collaborate with health systems and research groups to elucidate, on a large scale, genetic factors that cause or influence a range of human diseases. Building upon Regeneron's strengths in mouse genetics and genetics-driven drug discovery and development, the Center will specialize in ultra-high-throughput exome sequencing and computational biology; discovery of genotype-phenotype associations through linkage to well-annotated de-identified patient electronic medical records; and validation of discoveries using Regeneron’s VelociGene® technology. Our interests encompass a breadth of different areas such as Mendelian and family frameworks, large-scale population genetics (both common and rare variants), and gene-gene interactions. Program goals include target discovery, indication discovery, and patient-disease stratification. Objectives include advancing basic science around the world through public sharing of discoveries, providing clinically-valuable insights to physicians and patients of collaborating health-care systems, and identifying novel targets for drug development.

We are looking for a Senior Staff Scientist/ Senior Manager/Associate Director in our Translational Genetics Group. The position will take on responsibilities for the design, execution, and interpretation of genetics studies, as part of the Translational Genetics team, and in collaboration with Analytical Genetics team and the genome sequencing and informatics production teams. Primary responsibilities will be to lead for genetics discovery projects, new programs/collaborations, and to support the development of overall scientific strategy. Goals of the team will be to apply genetics to target discovery, selecting indications for drug programs, and patient/disease stratification through genetic association analyses and functional biology studies.

Responsibilities will include, but are not limited to:
• Manage a clinical/translational genetics team consisting of human genetics scientists, bioinformaticians, or other required staff to lead genetics studies and projects.
• Lead the design, execution, and interpretation of genetics studies for the center and collaborate with external partners and internal Regeneron scientists in such efforts.
• Work with research and clinical colleagues at Regeneron to introduce human genetics evidence and studies into current research plans and to support drug development efforts.
• Provide human genetics expertise and consult on projects within other R&D departments at Regeneron including therapeutic focus area teams, translational and predictive medicine, and clinical development.
• Survey the literature and conferences for discoveries and findings from the broader genetics community. Integrate such findings into study opportunities and considerations internally.
• Communicate and report study findings and analyses with leadership, administration, and collaborators.


Experience and Required Skills:
• This position requires an MD or PhD with at least 3-5 years of experience in human genetics research and a translational genetics focus. Additional requirements include:
• A strong preference for board certification or clinical expertise in clinical genetics
• Demonstrated ability to design and lead human genetics studies delivering novel genetic findings and medically relevant gene discoveries.
• Familiarity with statistical genetics and experience leading a breadth of study designs and analyses spanning family and Mendelian studies, population based studies, imputation, genotype-phenotype association studies, etc.
• Involvement in or use of large scale WES/WGS data sets such as GO-ESP, 1,000 Genomes Project, CHARGE consortium, Centers for Mendelian Genomics, etc.
• Experience with multiple platforms (chip-typing, WES & WGS, Sanger, custom capture targeted sequencing, etc) as well as other genomic profiling technologies (microarrays, RNASeq, etc).
• Experience with molecular characterization and functional studies geared towards elucidating gene functions and the mechanistic basis for genetic associations.
• Familiarity with clinical genetics and various genetic models of disease.
• Level commensurate with experience

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron Genetics Center’s unwavering commitment to combining good science & good business.

To all agencies:
Please, no phone calls or emails to any employee of Regeneron or the Regeneron Genetics Center about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron or the Regeneron Genetics Center via-email, the internet or in any form and/or method will be deemed the sole property of the Regeneron Genetics Center, unless such search firms/employment agencies were engaged by Regeneron or the Regeneron Genetics Center for this position and a valid agreement with either Regeneron or the Regeneron Genetics Center is in place. In the event a candidate who was submitted outside of the Regeneron or Regeneron Genetics Center agency engagement process is hired, no fee or payment of any kind will be paid.
RGC is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, disability status, protected veteran status, or any other characteristic protected by law.

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