Sr Scientist, Molecular Biology

Organization
Codiak BioSciences
Job Location
19 Presidential Way
Woburn, MA 01801
Salary
Competitive
Benefits

Our employees dedicate themselves to helping us achieve important goals. In return, we are committed to offering compensation and benefits packages that support and reward their contributions.

Job Description

Codiak BioSciences is seeking a Sr. Scientist, Molecular Biology.   The incumbent will be a key contributor to R&D program development at Codiak, collaborating closely with colleagues across R&D to drive programs from conception through development and providing subject matter expertise in molecular biology, biochemistry and cell biology. The candidate will serve as a core team member as well as a leader on various project teams. Primary responsibilities include the design and generation of mammalian expression constructs, the cultivation and engineering of mammalian cell lines to produce extracellular vesicles (EVs) with desired therapeutic properties, and the development of novel cell-based and in vivo assays for evaluating the functionality, target engagement, and potency of engineered EVs. The candidate will be responsible for managing both internal and external resources to generate critical protein, cell line, and EV reagents as well as oversee the generation and characterization of genetically engineered mouse models in a timely and efficient manner.

This position requires fluency in the scientific concepts that underlie relevant methodological approaches, as well as the ability to design and conduct appropriate experiments to test hypotheses, especially those related to the engineering of EVs and determining the effects of EVs on recipient cells. The successful candidate will have excellent organization and communication skills, the ability to collaborate effectively, and an enthusiasm for problem solving and mentoring. As part of a growing start-up company, the incumbent will be uniquely exposed to a broad range of activities both inside and outside of the laboratory.  We are also open to different levels for this role.

Responsibilities to include:

  1. Scientific and technical supervision of research associates, including mentoring and training, coordination of activities, setting timelines and assigning responsibilities;

  2. Individual contribution at the bench to establish capabilities in genome editing, cell and EV engineering, and cell-based and in vivo assays and imaging;

  3. Regular communication of results to project teams and senior management;

  4. Composing scientific presentations, written research reports, patent filings, and external publications;

  5. Other duties as required.

Requirements

The candidate will have a Ph.D. in Molecular Biology, Cell Biology, Biochemistry or related field; 7 – 12 years of combined post-doctoral industrial and/or academic experience; Extensive hands-on experience in molecular biology and biochemistry techniques such as molecular cloning, protein expression and purification, lentiviral transduction, mammalian cell culture, research cell line generation, flow cytometry and FACS; In-depth knowledge of state-of-the-art genome editing methodologies such as CRISPR/Cas9, ZFN, and TALEN approaches. Experience with lentiviral genome-wide CRISPR screening would be highly valued; Experience with cellular assay development involving siRNA, shRNA and antisense RNA; Experience with standard molecular biological and analytical techniques, including PCR, RT-qPCR, RNA isolation and analysis, SDS-PAGE, ELISA and western blotting.

About Our Organization

 

“If you treat employees as if they make a difference to the company, they will make a difference to the company.”

Doug Williams, PhD, President and Chief Executive Officer

That’s been the employee-focused philosophy behind Codiak BioSciences (“Codiak”) corporate culture since the company’s founding. At the heart of this business model is a simple idea: satisfied employees create great science.

From managers who work on projects alongside their staff members, to flexible scheduling that allows employees to work hard and play hard, the environment at Codiak is designed to enable employees to do great work and to have a life outside of work as well.

Vision

Be the pre-eminent Exosome based therapeutics and diagnostics company.

Company Background

Codiak is leveraging recent advances in the biology of extracellular vesicles and their role in intercellular communication. Codiak aims to become the world’s leading company in developing exosomes as a new therapeutic and diagnostic modality for the treatment of a wide array of diseases, including cancer. Recent discoveries have demonstrated that exosomes derived from normal cells can act as a potent and safe delivery system for multiple therapeutic payloads. These small vesicles, which leave cells and travel throughout the body, can mediate dramatic effects in animal models of disease. The group has also shown that exosomes derived from cancer cells contain specific proteins on their surface that can be used to quickly detect and characterize cancer from a sample of patient’s blood. They can also be used to monitor the response to cancer treatment, and to detect relapses.

At Codiak, our future products will enhance the lives of individuals all around the world. Our commitment to developing and providing these products ensures we continue to make a positive social and economic impact upon society.  As part of the Codiak team, we hope you will find the pursuit of this commitment both emotionally and financially rewarding.

Our success is built by creative and productive employees who are encouraged to make suggestions while being thought leaders and pioneers.  We achieve this through dedicated hard work and focused commitment from every employee. It is the desire of Codiak to have everyemployee succeed in their job, be part of achieving our collective goals, and be recognized for their contributions.

Location

We are currently located in Woburn at 19 Presidential Way but will be relocating to 500 Tech Square Cambridge in December 2016.


 

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