Sr. Scientist, Early Development Technologies

Roche Sequencing
Job Location
Pleasanton, CA
Job Description

Early development identifies and tests cutting edge reagents, technologies or protocols that are supporting the development of products in Oncology, Genetics, Infectious Disease and Automation/Sample Preparation. Areas of interest include short and long read sequencing technologies, low input and difficult sample preparation methods and creating integrated workflows. Candidates must be able to work in a collaborative, exciting, and fast-paced team environment. Also responsible for operating and maintaining equipment, interacting with LIMS databases, completing projects in a timely fashion, research and development, and giving presentations at weekly meetings.

Essential Roles and Responsibilities:

  • Experience with short and/or long read sequencing technology
  • Operation of different genomics analysis technologies such as microarrays, real time PCR and ancillary equipment for quality control and validation.
  • Develops, validates, and applies methods for various genomics methods mainly focused on sequencing.
  • Processes include nucleic acid isolation and quantification, PCR amplification, library preparation, plate normalizations and.
  • Working with senior personnel, performs early development activity to create new workflows that are robust, cost-effective and time efficient.
  • Collaborates with R&D to transfer new assays and methods to automation platforms.
  • Works closely with IT group and instrument vendors to develop and implement automated workflows.
  • Develops project timelines and utilizes time management practices and tools to manage demands and deadlines and to deliver on key project milestones.
  • Accurately and consistently records experimental methods, materials and results in electronic laboratory notebooks.  Analyzes data, evaluates results, forms conclusions, and determines future experiments.
  • Uses broad knowledge of molecular biology technique to proactively troubleshoot assays, to resolve technical issues and challenges, and to perform data interpretation.
  • Presents findings or comprehensive project status reviews at internal/external seminars/meetings.  Applies advanced technical writing and graphical skills to produce reports and documents.  Prepares summaries, reports, presentations, manuscripts, etc.
  • Writes and implements standard operation procedures SOPs .
  • Presents early development work including scientific background information and project updates at internal staff meetings and at cross-functional team meetings.
  • Determines all chemicals, reagents and supplies needed for a project; develops a strong knowledge of all related third-party vendors and their technologies and products.
  • Establishes and maintains productive relationship with personnel in development; orients and trains new employees.

Required Experience:

  • Strong molecular biology background
  • Experience performing  next-generation sequencing methods (Exome, whole genome, RNA sequencing)
  • Ability to write SOP
  • Excellent communication skills

Preferred Experience:

  • Ability to operate LIMS
  • Experience in: Laboratory automation/liquid handling; Microarrays (Affymetrix and Illumina; Real-time PCR; Advanced molecular biology techniques used in Genomics
  • Next-generation sequencing using Illumina instruments such as HiSeq, Nextseq, MiSeq
  • GLP experience

Required Education and Qualifications:

  • Bachelor of Science with a minimum of 7- 10 years of lab experience (or combination of education and experience with advanced degrees). 
  • 3 years of experience with laboratory automation/liquid handling
  • 3 years of experience with next-gen sequencing using Illumina instrumentation
  • 7- 10 years of experience in molecular biology methods

Preferred Education and Qualifications:

  • Master of Science
  • Ability to program lab automation such as Hamilton Starlet and Beckman Biomek FX
  • LIMS experience (e.g. Genologics)


About Our Organization

As pioneers in sequencing with a rich heritage in diagnostics, Roche's Sequencing Unit is committed to a future that fosters innovation to provide solutions that enable scientific discovery and deliver clinical value – We are Changing Science and Changing Lives

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