Sr. Associate Scientist, Immuno-Oncology Biomarker Job

Organization
Celgene Corporation
Job Location
Seattle, WA
Job Description

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture

Context:
Celgene Corporation, headquartered in Summit, New Jersey, is an integrated global biopharmaceutical company engaged primarily in the discovery, development and commercialization of novel therapies for the treatment of cancer and inflammatory diseases through gene and protein regulation. Celgene R&D is at a critical and exciting phase of development. As it expands and integrates its portfolio, there is an opportunity for a dynamic and resourceful individual to lead our efforts in Immune Oncology at our new Therapeutic Center of Excellence in Seattle, Washington.

Summary:
Reporting to Principal Scientist, Immuno-Oncology, the candidate will work with the Immuno-Oncology team by contributing to biomarker development and translational medicine correlative studies. The successful candidate will have solid technical and project management experience, as well as enthusiasm for working in a team environment to develop new anticancer drugs. Knowledge of hematopoetic malignancies is desired.

Responsibilities:
• Actively participate in the development of immune cell assays for drug candidate evaluation, mechanistic studies, and biomarker development
• Evaluate innovative technologies for developing biomarker assays
• Assist in the coordination of external collaborations with academic and contract research laboratories
• Perform cell biology, molecular biology, and biochemical techniques including primary and tumor cell culture, lymphocyte activation and cytotoxicity assays, multi-parameter flow cytometry, ELISA, ELISpot, RT-PCR, RNA preparation, viral transduction, mammalian cell transfection, immunoprecipitation, and western blotting
• Perform a wide range of assigned research experiments with efficiency, accuracy and attention to detail, conduct analysis and report results
• Independently follow protocols and function with minimal supervision
• Contribute to design of experimental procedures and search literature for targeted information.
• Interact with manager and project team to review data and plan next steps
• Record experimental details and maintain laboratory notebook
• Cultivate positive and productive working relationships with colleagues
• Prepare and present work at group meetings
• Participate in maintenance of routine laboratory instrumentation and supplies
• Use instrumentation to perform basic experiments
• Flexible to changing priorities
• Respectful of laboratory safety policies and practices

Specific Duties:
• Execute, under supervisor’s direction, the development of in-vitro and ex-vivo assays to translate preclinical data into clinical biomarkers for advancing drug candidates through clinical trials
• Contribute to and help coordinate collaborative efforts, both internally and externally
• Generate, analyze, and report experimental results
• Participate in Immuno-oncology team meetings to present data and provide analysis
• Maintain familiarity with current techniques and procedures
• Assist with the evaluation of innovative technologies directly related to Immuno-oncology
• Contribute to the writing of non-clinical pharmacology study reports, invention disclosures, and contribute to the writing of investigator brochures, IND applications, regulatory annual reports, and other regulatory documents when appropriate.

*LI-JW1

Qualifications
Prerequisite:

B.S. or M.S. in life sciences or medical sciences and a minimum of 8 (B.S.) or 6 (M.S.) years directly relevant ...cont.

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