Job Location
Waltham, MA
Job Description

In the Next-Generation Sequencing (NGS) workflow, the Senior Scientist, Sample Preparation, is responsible for the development of an automated sample-preparation process upstream of the sequencer. The candidate’s responsibilities include assessment of existing sample-preparation process, setting up an automation platform, and adapting existing protocols to the automation platform according to project requirements.

The Senior Scientist will directly report to the Director of System Integration. The candidate will also be frequently reporting out intermediate work results to the matrix and line organization.

• Build a strong core competency around sample preparation within the system integration group.
• Define objectives and plan experiments required to meet project milestones.
• Supervise work of research associates on a scientific-level across NGS workflow.
• Establish quality control methods using either qPCR or BioAnalyzer
• Analyze KPI’s (key performance indicators) and TPM’s (technical performance measures) to drive continuous process improvement.
• Design and verify robust sample tracking methods (chain of custody).
• Collaborate with other R&D groups to meet project objectives, more specifically with NGS System Integration group in Hilden (Germany).
• Deploy GDP (good development practices) methods and SOPs in accordance w/ QIAGEN standards, methodologies and guidelines.
• Maintain project documentations in accordance with internal and external requirements.
• Contribute to development of intellectual property. 


• MS/PhD in Biochemistry / Molecular Biology
• At least 5+ years of relevant industry experience (NGS and adjacent technologies)
• Expertise in DNA extraction and purification from FFPE samples, PCR amplification, qPCR and BioAnalyzer
• Mandatory experience in assay development for DNA analysis (preferably next generation sequencing)
• Excellent understanding of the underlying sample preparation chemistries for NGS workflows
• Preferably some experience with automated liquid handlers (e.g. QIAsymphony)
• Very good troubleshooting and problem solving skills
• Strong technical writing and presentation skills

Personal Requirements

• Strong work ethic with emphasis on taking initiatives
• Light travel required (up to 10%)

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.

About Our Organization

QIAGEN is the leading global provider of Sample to Insight solutions to transform biological materials into valuable molecular insights.

QIAGEN sample technologies isolate and process DNA, RNA and proteins from blood, tissue and other materials. Assay technologies make these biomolecules visible and ready for analysis. Bioinformatics software and knowledge bases interpret data to report relevant, actionable insights. Automation solutions tie these together in seamless and cost-effective molecular testing workflows.

QIAGEN provides these workflows to more than 500,000 customers around the world in Molecular Diagnostics (human healthcare), Applied Testing (forensics, veterinary testing and food safety), Pharma (pharmaceutical and biotechnology companies) and Academia (life sciences research).

As of June 30, 2015, QIAGEN employed approximately 4,400 people in over 35 locations worldwide. Further information can be found at

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