Senior Scientist, Protein Biochemistry

Organization
AbbVie
Job Location
Lake County, IL
Job Description

Seeking a highly-motivated and experienced research scientist to join the Protein Sciences group at our corporate headquarters located in the Chicago area. The candidate will be working in a highly dynamic group to provide protein biochemistry support for a newly formed team focused on the therapeutic potential of the ubiquitin proteasome system (UPS). This individual will function as a core-team member of the newly formed inter-disciplinary team, and contribute significant scientific advances to meet project goals. The applicant should be highly skilled in recombinant protein engineering and purification. He/she should have extensive experience working with multi-subunit complexes and working with different expression systems and have a solid understanding of structural biology, protein sciences, biophysics and enzymology. Experience of working with E3 ligases family proteins is highly beneficial. Hands-on experience in molecular biology, protein expression, and other protein characterization techniques will be a strong plus. 
Key Responsibilities: 

• Express and purify proteins to support assay development, HTS screen, biophysical assays and crystallization. 
• Critically QC protein reagents for different applications. 
• Closely work with project biology group to understand project needs and design proper experiments 
• Read literature to provide clone design ideas and other protein biochemistry suggestions 
• Evaluate scientific literature critically and adopt novel technologies to facilitate research 
• Work independently on the design, execution, and interpretation of experimental results



Requirements: 


Basic Qualifications: 

• Bachelors, Masters, or PhD in Biochemistry, Biophysics or related field 
• 0+ (Ph.D), 8+ (MS) or 10+ (BS) years of relevant academic and/or pharmaceutical industry 
• Experience with Ubiquitin Proteasome system essential 
• Extensive experiences in the area of making recombinant proteins for assay development, biophysical studies and structural studies. 
• Good problem-solving skills, capable of finding innovative ways to overcome issues (i.e. solubility, purity, heterogeneity, yield) with challenging proteins. 
• Fermentation and molecular biology experience will be a strong plus. 
• Strong communication skills and the ability to contribute in a multidisciplinary environment are essential. 
• Good record keeping and the ability to manage several projects simultaneously in a dynamic environment. 
Preferred Qualifications: 

• 3+ years of academic or industry experience 
Key Leadership Competencies: 

• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance. 
• Learns fast, grasps the "essence" and can change course quickly where indicated. 
• Raises the bar and is never satisfied with the status quo. 
• Creates a learning environment, open to suggestions and experimentation for improvement. 
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.

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