Senior Scientist, Organic Synthesis

Pacific Biosciences
Job Location
1380 Willow Road
Menlo Park, CA 94025
Job Description

Pacific Biosciences is looking for a Senior Scientist, Organic Synthesis to manufacture our fluorescent compounds. In this position the person will work on process optimization, scale-up and manufacturing of the targeted compounds. The candidate will need to be capable of performing activities required while developing and optimizing the synthesis and purification processes associated with our dye labeled compounds for yield, performance and quality. This position requires in-depth relevant experience in organic synthesis with the capability to support and maintain robust, reliable and accurate processes in manufacturing.  
This person will interface with a broad range of functional groups, and needs to have good communication skills. As a developer, this person will be responsible for correlation of processes and physical specifications to system performance metrics.

• Route selection for the most efficient way to synthesize the required compounds.
• Extensive lab work designing and executing experiments, and analyzing resultant data.
• Process optimization and scale-up.
• Establishing the right set of the documentation, related to products production.
• Collecting and analyzing the analytical data.


• Ph.D. in Organic Chemistry with 3 – 10 years of relevant industry experience in Pharmaceuticals/Life Sciences.
• Extensive experience in organic synthesis, process optimization and scale-up.
• Experience in fluorescent dyes and nucleotide synthesis is highly desirable.
• Strong knowledge in purification methods and analytical techniques.
• Knowledge and work experience in GMP environment is a plus.
• Must be hands-on.
• Strong communication skills, team work and initiative.
• Appreciation of process quality and specifications as a requirement for manufacturing.

About Our Organization

Pacific Biosciences’ mission is to transform the way humankind acquires, processes and interprets data from living systems through the design, development and commercialization of innovative tools for biological research. The company has developed a novel approach to studying the synthesis and regulation of DNA, RNA and protein. Combining recent advances in nanofabrication, biochemistry, molecular biology, surface chemistry and optics, Pacific Biosciences has created a powerful technology platform called single molecule, real-time, or SMRT™, technology. SMRT technology enables real-time analysis of biomolecules with single molecule resolution, which has the potential to transform the understanding of biological systems by providing a window into these systems that has not previously been open for scientific study. 

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