Senior Scientist, Organic Chemistry

Pacific Biosciences
Job Location
Menlo Park, CA
Job Description

We are seeking an organic chemist to further the development of synthetic materials for our DNA sequencing program. This individual will be expected to contribute in a diverse research environment covering areas such as preparation of analogs for single molecule sequencing, photophysics of organic fluorophores, DNA purification technology, nucleotide chemistry, surface and polymer chemistry. We are looking for an individual with skills complementary to the extensive organic synthetic, fluorescent dye, and nucleotide chemistry capability currently at Pacific Biosciences.


• Synthesis of compounds to further single molecule research and development

• Provide chemistry support to biochemistry, surface chemistry, and other groups which employ chemistry

• Perform experiments in collaboration with analytical chemists and biochemists


• Ph.D. in Organic Chemistry.

• 2 or more years postdoc or industrial experience.

• Experience in the following specialties is desirable:

- Solid background in organic synthesis

- Conjugation chemistry

- Comfortable in handling small scale ( 1-2 mg) reactions

- Experience with different types of column purification-normal phase, reversed phase HPLC, ion exchange, size exclusion etc

- Basic knowledge of molecular biology and experience of working collaboratively with analytical chemists, biochemists and molecular biologists

- Solid phase and polymer chemistry a plus

About Our Organization

Pacific Biosciences’ mission is to transform the way humankind acquires, processes and interprets data from living systems through the design, development and commercialization of innovative tools for biological research. The company has developed a novel approach to studying the synthesis and regulation of DNA, RNA and protein. Combining recent advances in nanofabrication, biochemistry, molecular biology, surface chemistry and optics, Pacific Biosciences has created a powerful technology platform called single molecule, real-time, or SMRT™, technology. SMRT technology enables real-time analysis of biomolecules with single molecule resolution, which has the potential to transform the understanding of biological systems by providing a window into these systems that has not previously been open for scientific study.

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