Senior Scientist, Enzyme Engineering, NGS Technologies (4393)

Job Location
Boston, MA
Job Description

Senior Scientist, Enzyme Engineering, NGS Technologies will be responsible for development of novel improved enzymes that will be used in Qiagen’s NGS workflows. These enzymes include sequencing enzymes for the sequencing by synthesis processes as well as novel enzymes used for nucleic acids amplification. In this role Senior Scientist, Enzyme Engineering will focus on near and long term improvements to existing Gene Reader workflows as well as perform research on novel internal and external technologies which will expand the range of applications and capabilities supported by future NGS workflows/platforms. The positon will have a key role in bringing innovative solutions to current and future NGS platforms and expanding the range of applications served by these platforms. Senior Scientist will be working closely with Sample Prep and Sequencing teams as well as Engineering, to ensure seamless integration of novel enzymes into QIAGEN’s NGS portfolio.

In this role Senior Scientist, Enzyme Engineering, NGS Technologies will:

• Investigate and develop technologies and approaches (internal and external) to development of novel sequencing enzymes with improved properties including mutaganesis, in silico design and in vitro evolution which significantly improve performance and capabilities of the Gene Reader workflow
• Work closely with Sequencing Chemistry developers to integrate novel sequencing enzymes into the Gene Reader workflows
• Evaluate external technologies and engage in external collaborations to bring novel technologies to QIAGEN’s NGS portfolio
• Play a key role in the development of future improvements, technological advances in the QIAGEN NGS platform and expansion of intellectual property
• Participate in collaborations with key external partners (industry and academia)
• Mentor and develop staff
• Deliver key insights into product application opportunities for the QIAGEN NGS platform


• PhD in Biology, Chemistry, Biochemistry, Bioengineering or related fields
• At least 5-10 years of relevant industry experience (NGS and adjacent technologies)
• Extensive experience with protein engineering based on rational design, mutagenesis, in silico design, and enzyme in vitro evolution
• Experience with protein purification and enzymatic activity measurements/assays
• Experience with diagnostic assay development and regulatory environment is a plus
• Excellent understanding of the underlying technical principles of next generation sequencing chemistries and workflows, associated instrumentation platforms and data analysis and interpretation algorithms
• Mandatory experience in next generation sequencing (NGS) technology development (DNA amplification, sample preparation, chemistry, instrumentation)
• Very good troubleshooting and problem solving skills
• Proven leadership and successful decision-making qualities
• Strong technical writing and presentation skills
• Moderate travel required (up to 10%)

How to Apply

If interested, please apply online

About Our Organization

As the innovative market and technology leader, QIAGEN creates sample and assay technologies that enable access to content from any biological sample.

Our mission is to enable our customers to achieve outstanding success and breakthroughs in life sciences, applied testing, pharma, and molecular diagnostics. We thereby make improvements in life possible.

Our commitment to the markets, customers, and patients we serve drives our innovation and leadership in all areas where our sample and assay technologies are required.

The exceptional talent, skill, and passion of our employees are key to QIAGEN’s excellence, success and value.

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