Senior Scientist Bioinformatics - Cancer

Organization
AstraZeneca
Job Location
Waltham, MA
Job Description

AstraZeneca is currently hiring a Scientist/Sr/ Scientsit to join our oncology Bioinformatics Team.  This team works with our oncology drug project teams from new target discovery to early clinical trials. The global group, currently 10 full time positions plus 3 post-doctoral roles, balance activities between three areas of focus: disease characterization and target discovery; drug project support; and clinical biomarker translation.

There is an exciting opportunity for a talented and motivated bioinformatician, knowledgeable in the genetics of cancer or immunology, to join the group. The post holder should be eager to bring genomic and phenotypic data together in new ways to reveal actionable insights surrounding complex biological problems.

Accountabilities/Responsibilities

  • Work with wet-lab and clinical scientists as part of oncology drug project teams to drive cutting edge science through application of bioinformatics/genomics.
  • Generate actionable biological insight from genomic (including next-generation-sequencing) data from patients and in vitro/vivo models.
  • Find new ways of analyzing, modelling and visualizing multi-omic and phenotypic data to discover and interpret meaningful patterns and relationships.
  • Publish high impact papers in peer reviewed journals.
  • Proactively engage in knowledge sharing and peer support across disciplines.
  • Train and build tools for our bench science community to effectively access key data.
  • Collaborate with academia and across industry, and exploit external resources, to find the most effective solutions to the key challenges in oncology drug discovery.
Requirements

Education:

  • Undergraduate degree and relevant PhD (or equivalent graduate degree plus experience) combining expertise in:
    • Oncology, immunology, or genetics/genomics of human disease.
    • Bioinformatics, computational biology, or biological data modeling.
    • Additional post-doctoral or applied experience in a relevant field is desirable.

 Essential

  • Understanding of the biological systems and signaling involved in human disease.
  • Expertise in genetic (DNA sequence and variant) data interpretation.
  • Proficiency analyzing and interpreting data from multiple 'omic platforms inc. NGS.
  • An enthusiasm to explore non-traditional approaches to bring big data together in biologically meaningful ways.
  • Skilled in effective communication of complex data to a non-expert.
  • Programming in a Unix and Windows environment.
    • R (inc. use of Bioconductor) proficiency
    •  Python/Perl experience.
  • Valuable contributions to scientific projects recognized through peer reviewed publication.

Desirable:

  • Deep understanding of the molecular drivers of cancer or immunology.
  • Experience/exposure to pharmacology data or clinical endpoints.
  • An excellent publication track record.
  • Expertise applying mathematical or network approaches to find patterns in molecular/phenotypic data.
  • A thorough understanding of the contribution of bioinformatics to drug discovery.
  • Well networked within external bioinformatics and oncology communities.
  • Awareness of large-scale pattern recognition techniques (graph modeling, machine learning, Bayesian analytics).
  • SQL/Database management expertise.
  • Effective contributions to collaborative projects involving cross-disciplinary and global teams
About Our Organization

 AstraZeneca is a global, science-driven biopharmaceutical company. We are dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients. The vision of AstraZeneca Oncology is to redefine cancer, redefine our solutions to cancer, and restore patients' lives.

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