Senior Scientist

Mount Sinai Genetic Testing Lab - Connecticut
Job Location
Branford, CT 06405
Job Description

SUMMARY: The Mount Sinai Genetic Testing Lab in Branford, Connecticut is seeking a motivated, results-oriented Senior Scientist to join our molecular diagnostic team.  With minimal supervision, the Scientist will assess new technologies and drive development and validation of new methods and diagnostic tests.  The ideal candidate will have experience with both research and clinical specimens in a high throughput, dynamic lab environment employing NGS technologies.  Using a working knowledge of state-of-the-art molecular techniques, the Scientist will work closely with the Bioinformatics and Lab Operations teams to execute proof of concept experiments and oversee successful deployment of new assays. 


Primary Duties and Responsibilities:


• Work across departments (Production Informatics, Project Management, Quality 

  Assurance, etc.) to design and validate new lab procedures and diagnostic tests.

• Actively drive continuous improvement activities regarding current methods and


• Working with pathologists, geneticists, Survey molecular diagnostic landscape to  

  identify current and emerging technologies  

  to assess.

• Draft and execute Reports, and Verification Plans and Summaries.  

• Drive successful transfer of standard operating procedures and tests to Lab Operations 

  team.  Monitor and report key performance indicators of new diagnostic and research-

  oriented tests.       

• Draft and provide content for SOPs. 

• Strict adherence to local, regulatory, and Quality guidelines to ensure full



• BSc, MSc, or PhD in life science-related discipline.

• 2 - 10+ years experience with standard molecular techniques:

  • PCR, qPCR, electrophoretic methods, DNA quantification, purification, and pooling methods, enzymatic manipulations, and primer design. 

  • NGS library preparation and chemistry expertise.  Including, but not limited to, Ion Torrent Ampliseq Agilent SureSelect methods. 

  • Experience with operating and programming liquid handling systems is preferred.

• 2+ years experience operating or supporting NGS systems.  Experience with multiple

  platforms is preferred.   

• 2+ years experience developing and performing constitutional genetics and/or

  molecular pathology diagnostic tests in CLIA/CAP facility. 

Physical Requirements:

• Use personal protective equipment.

• Stand or sit for extended periods of time, potentially performing repetitive motion.

• Work with potentially toxic, flammable, and corrosive chemicals, in addition to biologic   


• Able to lift 30lbs.

• May be asked to work weekend, irregular, or overtime hours.

• Exposure to potentially infectious clinical specimens in a biological safety level  

  laboratory environment.

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