Senior Scientist

Job Location
458 Brannan St.
San Francisco, CA 94107
Job Description

Miroculus is inviting applications from senior scientists who can lead the assay development effort on NGS processes as they move through the product pipeline. This is a cross-disciplinary position that will work closely with Molecular Biology, Chemistry, Microfluidics, QC, and Manufacturing, to develop and validate NGS workflows for product launch. Candidates must have a broad working knowledge of molecular biology, organic chemistry, or analytical chemistry and be able to apply it to provide immediate contribution toward NGS microfluidic-based technology development.

This role is laboratory-based and requires exceptional attention to detail for the meticulous execution and analysis of highly complex experiments. The ideal candidate will have already led to the successful launch of commercial products.

Key Responsibilities:

*  Drive the assay development of new products as they move from R&D into Manufacturing in preparation for commercial launch.  

*  Develop and optimize different NGS workflows.

*  Develop and implement novel QC methods to ensure processes are in control.

*  Design and conduct experiments to determine underlying reaction mechanisms, cause and effect, failure modes, guard band studies and optimization using DOE methodologies.

*  Independently troubleshooting formulation and QC issues.

* Productive execution of well thought out experiments, accurate recording of results along with in-depth analysis and reporting of these results.

We are looking for a creative and highly motivated individual. Our team is international, interdisciplinary, fast paced and used to excellent communication and teamwork skills. The candidate should feel comfortable functioning within a small and rapidly growing company.


Required skills:

* PhD (or equivalent experience) in molecular biology, organic chemistry, analytical chemistry, biochemistry, genetics, microbiology, chemical engineering, or related fields.

* At least 5+ years relevant biotechnology or pharma industry experience in product or process development.

* Demonstrated record of successful technology transfer from early R&D concepts into customer-facing products.

* Extensive experience in integrating chemistries onto instruments and troubleshooting

* Solid understanding of a wide variety NGS library preparation workflows.

* In depth knowledge of molecular biology techniques including PCR, qPCR, RT-qPCR, ddPCR, PAGE, and nucleic acid isolation and manipulation

* Ability to design meaningful experiments and perform in-depth analysis of results.

* Experience developing and implementing novel QC methods to assess reagent performance in both functional and orthogonal assays.

* Proven ability to write SOPs and train others to successfully perform the work.

* Strong collaboration and communication skills

* Desire to work in a flexible and fast-paced startup environment

Additional skills:

* Experience using statistical tools, such as JMP to analyze complex data sets.

* Previous work with custom reagent vendors and setting up OEM relationships.

How to Apply

To apply:

Please send a full CV together with a brief cover letter to by January 22nd.


February 2017, Full time position 

About Our Organization

Miroculus believes that everyone has the ability to make an impact, and we are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information.

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