Senior Scientist

AstraZeneca Pharmaceuticals
Job Location
Waltham, MA
Job Description

We are seeking a highly motivated and skilled PhD-level scientist with a strong immuno-oncology (IO) background to join the Oncology Bioscience team at AstraZeneca in Waltham, MA. The successful candidate will be expected to provide input to the overall immuno-oncology strategy, identify and validate novel small molecule IO target opportunities, elucidate mechanism of action and mechanism of resistance, develop biomarkers, and explore therapeutic combinations. The candidate will be responsible for establishing in vitro assays to determine functional effects of target activation/inhibition by using a variety of immune endpoints and will be expected to keep abreast of the published scientific literature. Additionally, the candidate will participate in assessing new technologies and building internal capabilities that contribute to the overall success of our small molecule drug discovery programs.

Major Responsibilities
Provide relevant scientific input to the overall immuno-oncology therapeutic strategy
Provide in-depth expertise and hands-on experience in developing rodent and human cell-based functional immunological assays, including flow cytometry, to establish a suite of relevant in vitro and in vivo assays
Identify and validate novel immuno-oncology therapeutic targets and pathways
Establish assays and identify biomarkers to elucidate mechanism of action of drug candidates
Explore drug resistance and potential combination strategies for immuno-oncology therapeutics
Summarize and present key findings to project and senior management teams
Present and publish key findings externally
Maintain understanding of scientific advances and competitive activity in immuno-oncology field
Lead new technology evaluations
Identify and manage external interactions and collaborations
Ensure safe laboratory practices


Minimum Requirements
PhD in Immunology or Immuno-Oncology field focused on relevant areas (immune evasion, suppression, etc)
3+ years of relevant post doctoral work in relevant areas (immune supression/evasion, T cell tumor biology, MDSC biology, etc.)
Direct experience developing cellular assays using a variety of immune cell endpoint
Hands-on multi-color flow cytometry experience
Outstanding oral presentation and written communication skills
Strong publication record of cutting edge research in cellular and/or tumor immunology

Preferred Background
Strong background in cancer biology
Pharmaceutical industry experience with understanding of drug discovery process
Familiarity with pros and cons of available in vivo tumor models to study tumor immunology
A strong background in the analysis of both innate and adaptive immunological responses

Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled/Sexual Orientation
LocationMA, Waltham
CategoryResearch and Non-Clinical Development
Date Posted12/11/2014
Req Number14-10054834
NoticeAstraZeneca does not accept non-solicited resumes or candidate submittals from search/recruiting agencies not already on AstraZeneca's approved agency list. Unsolicited resumes or candidate information submitted to AstraZeneca by search/recruiting agencies not already on AstraZeneca's approved agency list, and who were not asked to work on a specific vacancy, shall become the property of AstraZeneca and if the candidate is subsequently hired by AstraZeneca, AstraZeneca shall not owe any fee to the submitting agency.

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of cardiovascular, metabolic, respiratory, inflammation, autoimmune, oncology, infection and neuroscience diseases. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. For more information please visit

Making a Difference
AstraZeneca is an equal opportunity employer

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