Senior Research Scientist, Stamatoyannopoulos Lab | GenomeWeb

Senior Research Scientist, Stamatoyannopoulos Lab

University of Washington - Genomce Sciences Department
Job Location
Seattle, WA
Job Description

Requisition: #111773
Date Posted: 8/25/2014
Deadline to Apply: open until filled

The Department of Genome Sciences has an outstanding opportunity for a Research Scientist/Engineer Senior (RSE Sr). The RSE Sr will play a leading role in providing biological and genomic insight required to help steer the computational and informatics efforts of the lab. The person in this role will work to emphasize the efforts of understanding gene regulation, chromatin, regulatory variation, and its relation to human disease. He/she will also support the laboratory applications of high-throughput DNA sequencing methods for a variety of epigenomic assays, including DNase-seq, ChIP-seq for histone modifications and transcription factor binding, methylation analysis, chromatin capture analysis, and newer, cutting-edge methodologies currently under development in the lab.

The main responsibilities for this position are as follows:

• Formulate testable hypotheses relevant to the intellectual mission of the lab.
• Design specific scientific projects and experiments that translate regulatory genomics technologies to disease-focused research paradigms
• Work closely with laboratory experimentalists and informatics staff to plan and execute experiments and analyses
• Coordinate large-scale analysis efforts: formulate plans, set milestones, direct and supervise staff to accomplish specific aims.
• Perform customized analyses to solve specific research questions.
• Develop software and scripts designed to analyze genome-wide epigenetic datasets or facilitate dataset production.
• Maintain domain expertise by reading research papers, attending conferences, and maintaining collaborations with relevant investigators
• Prepare written manuscripts for publication; generate production-quality figures using publishing and mathematical modeling software
• Prepare and deliver oral and poster presentations on research results for conferences
• Assist in the organization and writing of grant proposals and project reports
• Attend Genome Sciences and University meetings, retreats, status updates, orientations and planning days when necessary.

Supervise more junior informatics staff in executing large-scale analysis efforts, when required

This position requires deep domain knowledge and research experience, as well as computational skills. The position requires communication and coordination with all levels of laboratory staff. The position directly impacts the success of the laboratory’s research mission by helping to set research priorities and then formulating plans to test hypotheses and execute experiments and analyses. It requires the ability to manage large-scale projects and supervise staff duties within those projects. The position requires maintaining and fostering relationships with University and non-University parties. The position demands organization, commitment, the ability to work alone and in complex teams, expertise in laboratory protocols, and expertise in DNA sequencing.


The ideal candidate will have a strong computational background as well as a strong biological background, ideally at the PhD level. Prior specific experience in the analysis or meta-analysis of human genotype or genome-wide association study (GWAS) data are highly desired.

• Ph.D. and postdoctoral fellowship in biology, genetics, or genomics-related field
• First-author publications within the field of training.
• Minimum of 4 years of laboratory and computational research experience
• Computational skills
o Proficient in a unix command-line environment
o Experience using GWAS-related packages for quality control, imputing genotype variants to a common reference, and computing associations: e.g., SNPRelate, SHAPEIT, IMPUTE2, PLINK/PLINK2, snpStats.
o Experience with high-level programming languages such as C/C++, Python, or Perl.
o Experience with Unix shell script programming (bash, csh, etc.)
o Experience with interactive mathematical packages such as matlab, Mathematica or R.
• Specific ability to interact with laboratory, regulatory, and computational scientists
• Excellent written and verbal communication skills
• This position requires a high degree of independence and problem-solving skills
• Pharmaceutical industry experience in genetic approaches to drug discovery
• Experimental assay design
• Experience managing research and laboratory staff
• Publication preparation software experience (Adobe Illustrator, Word)
• Experience in web development languages and frameworks, such as JavaScript, HTML5, JQuery and d3.js
• Ability to publish and share code via popular version control mechanisms, such as Git, SVN or Mercurial

How to Apply

For more information and to apply please see our full position announcement:

The University of Washington is an affirmative action, equal opportunity employer. Women, minorities, individuals with disabilities, and covered veterans are encouraged to apply.

About Our Organization

The University of Washington (UW) is proud to be one of the nation’s premier educational and research institutions. Our people are the most important asset in our pursuit of achieving excellence in education, research, and community service. Our staff not only enjoys outstanding benefits and professional growth opportunities, but also an environment noted for diversity, community involvement, intellectual excitement, artistic pursuits, and natural beauty.

The Department of Genome Sciences (GS) is part of the University of Washington School of Medicine (UW SoM) and is comprised of 27 labs addressing leading edge questions in biology and medicine by developing and applying genetic, genomic and computational approaches taking advantage of genomic information now available for a host of species. GS is making major contributions in the application of genome science to understand the fundamentals of biology and to improve human health and well-being.

Genome Sciences is a collaborative department supported by very different academic disciplines. We work with a multitude of Program Investigators (PIs) in departments both on the UW campus as well as worldwide. The department has gone through significant expansion since its beginning in 2001 with annual grant awards of $41.6 in FY13. The department has 47 training, teaching, and research faculty.

The University of Washington is an affirmative action, equal opportunity employer. Women, minorities, individuals with disabilities, and covered veterans are encouraged to apply.

Bitesize Bio offers some word of wisdom for designing a new lab.

A study finds that some women choose science majors later in their college careers.

The US National Labor Relations Board rules that graduate assistants have the right to unionize.

Sociologists find that dual-career programs are important for recruiting female academics, Inside Higher Ed reports.