Senior Research Associate (Next Generation Sequencing Support)

Lawrence Berkeley National Laboratory
Job Location
Walnut Creek, CA
Job Description

Senior Research Associate (Next Generation Sequencing Support) - 80404
Organization:  GN-Genomics

The Department of Energy (DOE) Joint Genome Institute (JGI) has an immediate opportunity to perform production and research assignments, data analysis and interpretation related to various technology in next generation sequencing (NGS) library construction and tasks. The work will meet the goals of the large-scale genome, transcriptome and epigenome characterization effort. Tasks involve evaluation of sample quality, library construction, library quality evaluation and submission using JGI LIMS systems. Will be responsible for understanding the latest sequencing technology, support or lead new technology development, integrate new protocols onto JGI sequencing platforms. Will also interpret sequencing QC (quality control) reports, analyze sequencing data, troubleshoot process failures and participate in optimization of protocols. Emphasis will be placed on research and development (R&D) experiments as well as meeting the library production goals.

• Perform work assignments related to library production; evaluate sample quality, create various types of libraries from samples (DNA, RNA or chromatin) from JGI users’ including prokaryote, eukaryote organisms, and environmental samples.
• Participate in technology development projects to support scientific research.  
• Independently design and execute experiments, analyze and interpret results, summarize and conclude data in presentable format.  
• Understand and interpret sequencing QC results, identify library failure, propose solution and implement modifications.
• Investigate library preparation issues relating to production needs, identify areas of improvement and offer feedback.
• Troubleshoot & optimize current library construction protocols to meet scientific research goals.
• Assist in project coordination with project management.
• Maintain an accurate and detailed laboratory notebook and ensure accurate data entry into ITS/ GLS LIMS system.   
• Write, update and maintain standard operating procedures.
• Prepare progress reports, attend and present project progress in group meetings.
• May maintain a clean and safe working environment.
• May contribute to data, text and conclusions in group publications.
• May assist in training staff to perform new molecular biology experiments and protocols.
• May research articles and literature to explore new techniques or applications.


• Relevant Bachelor’s degree plus two to five years of experience with increasing responsibility in Biology, Microbiology, Genetics or related field, or an M.S. degree
• Demonstrated ability to work independently; plan, analyze and summarize experimental data under minimal supervision
• Demonstrated experience with laboratory and molecular biology techniques including nucleic acid purification, NGS library preparation and sequencing, chromatin immunoprecipitation
• Proficient molecular understanding in DNA, RNA, chromatin sample processing and manipulation
• Fundamental understanding of NGS genomics data
• Efficient time management skills and ability to multi-task in a fast-paced environment
• Versatility in understanding new concepts, adapting to/applying new technologies
• Understanding of how scientific principles apply to problem being studied
• Experience troubleshooting process problems, conducting analysis of data and recording experimental data
• Demonstrated ability to serve as a technical resource, troubleshoot laboratory process problems and recommend process and database improvements
• Excellent analytical, recordkeeping and organizational skills necessary for working in a laboratory environment
• Effective interpersonal and communication skills to work in a research team environment with a diverse group of scientific and technical personnel
• Proficient computer skills

• Master’s degree
• Experience in NGS sequence data analysis/ interpretation
• Knowledge in gene expression and epigenetic regulations, genomics or algal biology
• Knowledge of environmental, health and safety, security, procurement and business management policies and procedures

Notes: This is a one-year term appointment represented by a union for collective bargaining purposes. Appointment extension and/or career conversion is possible and based on successful performance, continued funding and ongoing need. A background check is required.

About Us
Rapid technological advances in genomics have transformed modern biology. From its inception, the Department of Energy Joint Genome Institute has been at the forefront of large-scale sequence-based science. Learn more about JGI happenings ( at and

Lawrence Berkeley National Laboratory addresses the world’s most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Berkeley Lab’s science is a global enterprise. Our scientists work at the frontiers of knowledge to better understand our universe and to address the challenges facing our nation and our planet. Read about our excellent benefits (  

Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age or protected veteran status.

How to Apply

Apply directly online at and follow the on-line instructions to complete the application process.

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