We are looking to appoint a research associate experienced in molecular immunology and/or genetics to join the research group led by Kaan Boztug at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences.
The focus of the group is to understand the molecular mechanisms governing the immune response by discovering inherited defects of the human immune system and studying the resulting pathomechanisms. To achieve this the Boztug laboratory fosters interdisciplinary research consisting of state-of-the-art next-generation sequencing (NGS) approaches to genetically characterize affected individuals, cellular and molecular approaches to assess the immune system function and systems biology proteomic and genomic approaches to elucidate novel molecular pathways governing the human immune system. Ultimately, understanding the immune response at the molecular level will lead to better treatment options (as exemplified by a number of recent group publications, e.g. Salzer E et al JACI 2014, Boztug K et al Nature Genet 2014, Willmann K*, Klaver S* et al Nature Comm 2014, Dobbs K*, Dominguez Conde C*, Zhang S-Y*, Parolini S* et al New Eng J Med 2015).
This challenging multifaceted position requires a highly dedicated and motivated person who will substantially contribute to:
- The ongoing research projects focusing on (I) autoimmune disorders including inflammatory bowel disease and SLE-like syndromes, (II) disoerders of the primiarily adaptive immune system ((severe) combined immunodeficiencies (S)CIDs) and (III) disorders of the myeloid lineage through research design and supervision of the scientific staff.
- Knowledge dissemination and fundraising activities through writing research publications and grants.
- Administrative support to the research projects such as ethics approvals and periodic reporting to granting agencies.
- Optimization of genetic testing workflow in the lab through organization of standard operating procedures for genetic testing, interaction with clinical partners, overlooking the patient sample and clinical data organization.
- Keeping track of advances in the NGS-based technologies for identification of inherited defects of the human immune system (so-termed “primary immunodeficiencies”, PIDs).
- Keeping track of newest research literature in the field of primary immunodeficiencies and participating in the regular lab meetings and journal club series.
- Finally, there is a strong incentive for the candidate to develop and manage own research project through supervision of PhD students and technical staff, which offers an attractive opportunity for professional development of the selected candidate.
The Lab Infrastructure
A fully equipped molecular biology laboratory in a shared environment with cell culture and multi-color flow cytometry on the same floor within a brand new building. All equipment needed for state-of-the art genomic investigations such as SNP arrays and deep sequencing are immediately accessible on the same floor of the building. The group is embedded in a multidisciplinary and highly collaborative systems biology/molecular medicine research environment providing access to state-of-the-art mass spectrometry, bioinformatics, automated chemical biological screening platform and animal facilities, including BSL2 suites.