Senior Research Associate (Genome Sciences)

Lawrence Berkeley National Laboratory
Job Location
Walnut Creek, CA
Job Description

Senior Research Associate (Genome Sciences) - 79936
Organization: GN-Genomics

The Genomics Division at Lawrence Berkeley National Laboratory (Berkeley Lab) has an immediate career opportunity for a Senior Research Associate (SRA). This position is part of the Berkeley Drosophila Transcription Network Project, a large, interdisciplinary functional genomics project. Under general supervision of a scientist, the SRA will perform, test and optimize protocols for the high throughput analysis of transcription factors that regulate Drosophila development. Will also analyze the in vitro and in vivo DNA binding properties of sequence specific DNA binding proteins by various means, including protein expression in bacterial and insect cells, protein purification, SELEX assays, gel shift assays, in vivo crosslinking, and immunoprecipitation. In addition, help oversee day-to-day laboratory operations, such as the ordering and maintaining equipment and supplies.

• Perform experiments related to the analysis of protein/DNA interactions of animal transcriptional regulatory proteins.
• Organize and perform large-scale projects such as the expression and purification of large numbers of proteins, the analysis of their DNA binding properties, and the isolation of crosslinked chromatin.
• Independently design experiments and achieve milestones in a research environment.
• Independently perform, optimize, and provide input to the development of new biochemical protocols.
• Oversee the ordering of supplies, the repair of equipment, compliance with EH&S polices and procedures and other laboratory maintenance issues.
• Accurately prepare solutions, media and other reagents.
• Collaborate with other laboratory members.
• Participate in laboratory meetings and communicate results to other lab members
• Assist with organizing research results for informatic analysis, publication, and presentations.
• Maintain an accurate and detailed notebook describing experiments performed and quality control that ensures others could duplicate results.


• Research experience in protein biochemistry, protein purification, and biochemical assays is highly advantageous.
• Bachelor’s degree in Biology, Biochemistry, Molecular Biology, Genetics, Chemistry or related field plus two to five years of experience with increasing responsibility, or overall equivalent experience; MS preferred
• Knowledge and experience in general molecular biological techniques such as PCR, Southern blotting, sub cloning, DNA preparation, DNA sequencing, and sequence-specific mutagenesis
• Demonstrated ability to work successfully with members of a multi-disciplinary research team
• Effective written and oral communication and organizational skills
• Demonstrated ability to work independently and maintain an accurate laboratory notebook
• Mac or PC computer and associated software packages, such as Word, and Excel; ability to learn custom software applications
• Preferred - Knowledge of transcriptional regulation and Drosophila biology
• Preferred - Hands on experience in genome sequencing or functional genomics related activities such as physical mapping, library creation, subclone sequencing, or data management (informatics)
• Preferred - Familiarity with the robotics platforms (such as Tecan, and Biomek) commonly used for high-throughput molecular biology protocols and biochemical assays

Notes: This is a career appointment represented by a union for collective bargaining purposes. Work will be performed at the Lawrence Berkeley National Laboratory in Berkeley, CA. A background check is required.

How To Apply
Apply directly online at and follow the on-line instructions to complete the application process.

Requested application materials: As part of the online application, please provide 1-2 reference contacts in addition to uploading a resume and brief cover letter.

About Us
The Berkeley Drosophila Transcription Network Project is a multidisciplinary team centered at Lawrence Berkeley National Laboratory and UC Berkeley. Our goal is to decipher the transcriptional information contained in the extensive cis-acting DNA sequences that direct the patterns of gene expression that underlie animal development. Using the early blastoderm embryo of the fruit fly Drosophila melanogaster as our principal model, we are developing experimental and computational methods to systematically characterize and dissect the complex expression patterns and regulatory interactions already present prior to gastrulation.

Lawrence Berkeley National Laboratory addresses the world’s most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Berkeley Lab’s science is a global enterprise. Our scientists work at the frontiers of knowledge to better understand our universe and to address the challenges facing our nation and our planet. Read about our excellent benefits -

Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age or protected veteran status.

How to Apply

Apply directly online at and follow the on-line instructions to complete the application process.

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