Senior Engineer - Process Control Analysis

10X Genomics
Job Location
San Francisco Bay Area, CA 94566
Job Description

10X Genomics is a Bay Area start-up developing new technologies for breakthrough next generation sequencing applications. The core technology combines advances in chemistry, biochemistry, microfluidics and computational biology.


10X is looking for an outstanding individual to join its consumable and reagents development team. This is a key position for the commercialization of consumable products associated with Next Generation Sequencing chemistries. This person will be responsible for developing and integrating process control and yield optimization solutions for complex reagent manufacturing workflows.


The ideal candidate will have a strong background in statistics and data analysis.  Knowledge and hands on experience with trend analysis, yield enhancement methods, correlation and ANOVA analysis, quality systems databases, developing statistical process control for reagent manufacturing and previous experience in manufacturing SPC are required.


Key Responsibilities

  • Develop and implement process monitoring for robust manufacturing of complex reagents.
  • Write custom database queries to extract and aggregate QC data from multiple databases, analyze this data and establish trends and guard bands for process control.
  • Identify key parameters and establish statistically relevant correlations between regent QC metrics and next gen sequencing metrics.
  • Contribute to CAPA investigations and remediation.  Provide data analysis and support for root cause investigations. 
  • Provide guidance for expansion of data collection activities to R&D organization.  Develop light weight sample tracking and automated data collection for subsequent sequencing.
  • Produce reports on process / method capabilities, component variability and ANOVA.
  • Advanced degree in Statistics, Biophysics, Chemical, or Manufacturing Engineering or related field, with an emphasis in statistical process control and monitoring.
  • BS with 5+ years of experience, or MS / PhD with 1-3 years of experience.
  • Relevant experience developing process control for the manufacture of successful products.
  • Previous experience programming databases is required.  Experience with Postgres databases and NetSuite Advanced Manufacturing highly desired.
  • Ability to work with scientist and engineers to establish correlations between QC data and sequencing metrics.  Ability to identify potential sources of root cause.
  • Familiar with illumina next gen sequencing data and key sequencing pipelines and metrics.
  • Experience with standard statistical analysis software (e.g. JMP, CHARTrunner, Minitab, Matlab) is required.
  • Desire to be part of a rapidly evolving organization, with a compelling technology, and taking products and processes to the next level.
How to Apply
About Our Organization

10x Genomics meets the critical need for long range, structural and cellular information, with an innovative system that transforms short-read sequencing technologies. Our ChromiumTM System supports comprehensive genomics and high-throughput single cell transcriptomics. It enables researchers to discover previously inaccessible genomic information at unprecedented scale, including phased structural variants, phased single nucleotide variants, and dynamic gene expression of individual cells—while leveraging their existing sequencing systems and workflows.


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