Senior Director, NGS Process Engineering

New York Genome Center
Job Location
New York, NY 10013
Job Description
  • Responsible for leading the entire process-engineering effort at NYGC; requirements definition, design, development, optimization, troubleshooting, verification, validation, and transfer of automated processes, systems and workflows for NGS and analysis.

  • Ensure that all methods, protocols, work practices, SOPs, analysis and other processes across the entire sequencing and informatics groups are efficient, optimized for cost- savings, and are an optimal allocation of resources.

  • Evaluate current sequencing operation and data analysis procedures for optimization and improvement:

   o Work with internal stakeholders to encourage and gather feedback and suggestions, and drive the establishment of process requirements.

   o Present recommendations for changes, establish realistic timelines for execution, and communicate with partners.

   o Lead agile implementation of changes, and ongoing evaluation, incorporating input from other team members efficiently and effectively. Work with diverse partners to ensure that developed processes are robust, scalable and meet operational requirements.

   o Train and mentor employees to improve their understanding of process optimization and best working practices.

  • Work with Project Management and other teams to ensure our internal processes, systems and SOPs enable project deadlines to be achieved, and to reduce turn-around times, especially for clinical samples.

  • Work in cross-functional teams to provide troubleshooting expertise on developed processes.

  • Evaluate new methods, equipment and technologies to bring to the Center as needed, present recommendations to internal stakeholders, and lead or assist with implementation.

  • Drive forwards internal priorities cross-functionally to ensure swift implementation Including:

   o Work closely with the bioinformatics group to implement improved methods for QC, rapid analysis, fast annotation, and other developments that arise.

   o Work closely with the Innovation group and the Methods Development team to transition new technologies into the production lab.

• Ensure all regulatory requirements are appropriately adhered to. 

  • Ph.D. or equivalent in molecular biology, biotechnology, biochemistry, bioinformatics,

    genetics or a related field, and 10+ years’ related experience;

  • Broad-ranging managerial and process-engineering experience at a senior level in a

    high-throughput genomics laboratory;

  • Demonstrated ability to lead cross-functional process development, improvement, and


  • Experience in streamlining workflows and developing automated laboratory processes

    and systems, including collecting and documenting requirements, developing concepts,

    design, verification and validation, implementation, and transfer/training;

  • Solid knowledge of NGS, related protocols and equipment, including significant Illumina-

    specific NGS experience;

  • Solid understanding of NGS data analysis;

  • Demonstrated skill in troubleshooting techniques and assessing sequencing-run quality;

  • Ability to lead across departments and to influence, rather than directly manage;

  • Familiarity with Microsoft Word, Excel, PowerPoint, and LIMS systems;

  • Excellent communication skills, detail oriented, and highly motivated; and,

  • Strong creative thinking and problem-solving skills.


  • Automation experience;

  • Knowledge and experience of NYS regulatory approvals and/or CLIA environments;

  • Knowledge of project-management tools;

  • Knowledge and experience of IT systems for high-performance computing;

  • Knowledge and experience of software engineering responsibilities, processes, and

    extensive interactions with software engineering groups;

  • Experience of a high-throughput and/or commercial environment;

  • A positive attitude towards change; and,

  • Comfortable with risk. 

How to Apply

To apply, visit

About Our Organization

The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research.

The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities. 

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