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Senior Bioinformatics Scientist, Cancer Genomics

New York Genome Center
Job Location
101 Avenue of the Americas
New York, NY 10013
United States
Job Description

This position at the New York Genome Center is within the computational biology group and will report to the Assistant Director. As a Senior Bioinformatics Scientist, you will be responsible for applying and developing cutting edge analytic methods to large scale cancer exome and whole genome sequencing data generated at NYGC and elsewhere. You will work with collaborators throughout the city and other members of the NYGC computational biology team to provide novel insights into cancer mechanism and treatment, develop and maintain state of the art analysis tools, and analyze cutting edge data from new genomics technologies. Projects can range from large and diverse cohorts of tumor samples (such as generated in the NYGC Polyethnic-1000 project), longitudinal sampling of tumors, liquid biopsy, single-cell genomics (RNA, DNA or multi-modal), etc. You should have significant experience in cancer genomics, including familiarity with commonly used algorithms for alignment, variant calling, and structural variant calling and computational methods for inferring significantly associated somatic variation from cohorts of patients. Publication of developed methods and scientific findings is encouraged. The Senior Bioinformatics Scientist is expected to contribute as an individual but may also be asked to manage a small group working on cancer genomics.

Job duties will include, but may not be limited to:

  • Develop and implement innovative computational approaches for the analysis of large datasets generated by NGS technologies;
  • Contribute to management of next generation sequencing (NGS) data analysis pipelines;
  • Analyze sequencing data using the established pipeline(s);
  • Collaborate and consult with external and internal researchers on the analyses of NGS data;
  • Interpret and present the results of the computational and statistical analyses to collaborators and coworkers;
  • Assist collaborators with data access, analysis, and interpretation;
  • Supervise and guide bioinformatics analysts/programmers;
  • Contribute to strategic decisions about the cancer genomics efforts at NYGC;
  • Participate in grant application writing;
  • Publish results in scientific journals and give presentations at conferences; and,
  • Participate in community outreach.
  • Stay current on innovations in DNA sequencing analysis;
  • PhD. in bioinformatics, computational biology, genetics, computer science or similar;
  • 3 or more years work experience post-PhD in Bioinformatics and Cancer Genomics;
  • Experience managing and working with whole-genome sequencing data required;
  • Extensive knowledge and experience in the use of existing bioinformatics tools, biological databases and statistical methods for cancer genomics;
  • Excellent written and verbal communication skills required.
  • Proficiency in python and R required, and one or more programming languages such as Perl, Java, or C/C++ desirable, as well as willingness to learn new programming languages as necessary to collaborate at NYGC;
  • Experience working in Linux and running tasks in a cluster environment (e.g. SGE) required;
  • Experience working in teams centered around a biological question and with external collaborators required;
  • Experience with design of sequence analysis algorithms desirable; and,


  • Job Mastery- Knowledgeable of current role and technical skills, and the impact it has on the Center.
  • Continuous Learning– Strives to expand the depth and breadth of technical and professional skills.
  • Collaborative– Encourages participation from team members and works effectively with all levels.
  • Credible– Works with a high level of integrity.
  • Communicative– Actively listens to others and uses good judgement as to what to communicate to whom; provides feedback.
  • Focused – Utilizes efficient and effective processes.
  • Adaptable– Demonstrate flexibility with changing priorities.
  • Innovative– Develops new insights and pursues improvements.
  • Takes Ownership– Prioritizes tasks, manages time and delivers on commitments.

FLSA Status – Exempt

This position is eligible for visa sponsorship and relocation assistance. 


How to Apply

To apply, please visit

About Our Organization

The New York Genome Center (NYGC) is an independent, nonprofit, academic research organization dedicated to advancing genomic research. NYGC scientists and staff are furthering new approaches to diagnosing and treating neurological diseases and cancer through their unique capabilities in whole genome sequencing, RNA sequencing, state-of-the art analytics, and the development of genomic tools. NYGC concentrates specifically on disease-based research in the following areas: neuropsychiatric disease (autism, schizophrenia, bipolar); neurodegenerative disease (ALS, Alzheimer’s, Parkinson’s, Huntington’s), and cancer.

Located in Lower Manhattan, the New York Genome Center was founded by and remains closely affiliated with twelve leading academic medical centers and research universities in the New York region and beyond, engaging in research projects with and for these institutions. Essential to our collaborative work is an outstanding faculty, whose members typically hold a joint appointment at NYGC and a partner university. They support our scientific mission by conducting independent research in areas of mutual interest to us and the wider scientific community. 

The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, creed, color, gender, religion, national origin, sexual orientation, age, disability, genetic predisposition or carrier status, protected veteran or military status, domestic violence victim status, partnership status, caregiver status, alienage or citizenship status, marital status, or any other characteristic protected by applicable law. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

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