Senior Bioinformatics Engineer

Twist BioScience
Job Location
San Francisco, CA
Job Description

The Bioinformatics and Biosecurity group at Twist is currently seeking a Senior Bioinformatics Engineer to help scale DNA synthesis. In collaboration with biologists, chemists, physicists and software developers, the successful candidate will use a variety of methods including software development, algorithm development, statistics, and data visualization to analyze and interpret biological data including next generation sequencing results.


  • Developing scalable bioinformatics algorithms, pipelines and tools to solve complex, distributed computing challenges
  • Providing statistics, scientific computing and data analysis support to research, product development and manufacturing operations.

Required Experience:

  • BS in bioinformatics or related field with 6-8 years industry experience or MS/PhD in bioinformatics or related field with 4-6 years industry experience
  • Advanced proficiency in Python, R or Rust in a Linux environment
  • Broad experience with NGS data analysis, manipulation and presentation (in Python or R)
  • Excellent data analysis and visualization skills (in Python, R and using tools like Tableau)
  • Excellent understanding of molecular biology, with an emphasis on DNA chemistry preferred
  • Proven ability to synthesize and present conclusions from complex analyses in a clear and visually compelling way

Preferred Experience: 

  • Familiarity with common tools and file formats for genome-scale interval data manipulation and analysis (e.g. bedtools, bedops, etc.)
  • Formal software development experience, the software development lifecycle, unit and functional testing (via py.test) and version control via Git
  • Familiarity with database (PostgreSQL, NoSQL and Redshift) design, implementation and efficient query construction
  • Experience building and using Docker containers
  • Familiarity with cloud-based computing environments, especially Amazon Web Services
  • Experience using workflow management tools (e.g. Airflow, Galaxy, Luigi)
  • Familiarity with web application development including building REST-ful interfaces
  • Familiarity with DNA analysis software (MacVector, VectorNTI, SnapGene) 

US Citizens, EAD and Green card only. Background check, employment and education verification, and professional references are required.

How to Apply
About Our Organization

At Twist Bioscience, our expertise is accelerating science and innovation by leveraging the power of scale. We have developed a proprietary semiconductor-based synthetic DNA manufacturing process featuring a 10,000-well high throughput silicon platform capable of producing synthetic biology tools, including genes, oligonucleotide pools and variant libraries. By synthesizing DNA on silicon instead of on traditional 96-well plastic plates, our platform overcomes the current inefficiencies of synthetic DNA production, and enables cost-effective, rapid, high-quality and high throughput synthetic gene production, which in turn, expedites the design, build, test cycle to enable personalized medicines, pharmaceuticals, sustainable chemical production, improved agriculture production, diagnostics, biodetection and data storage. For more information, please visit Twist Bioscience is on Twitter. Sign up to follow our Twitter feed @TwistBioscience at

Twist Bioscience is an equal opportunity employer.

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