Senior Bioinformaticist

Rady Children's Institute for Genomic Medicine
Job Location
3020 Children's Way
San Diego, CA 92123
Job Description

We have an immediate opening a Bioinformaticist.

We are looking for superstar computational-biologists/bioinformaticists who have a demonstrated experience in a large-scale production setting to deploy, maintain and evolve the bioinformatics framework for a high-throughput; ultra-rapid turnaround time whole-genome sequencing based clinical setting. You will have the opportunity to be a part of a team that'll build the infrastructure ground up using the latest and greatest of the technologies in infrastructure, data storage and analytics, with a strong focus on automation and integration. The environment is highly cross-functional, with a rich medical research heritage and multitude of collaborations with the biotech industry, academic institutions and federal programs. The end deliverable from your work will tangibly influence the quality of life of the children being seen at the hospital making your work experience exciting, challenging, rewarding and meaningful. And to top it all, you'll be located in one the finest cities in the country, with a wonderful year-round weather and a multitude of outdoor activity options.
Depending on the level of relevant experience, your candidature will be considered for the (junior/senior) bioinformaticist positions.


Minimum Qualifications:

  • Bachelor's degree in Computer Science, Information Systems, Bioinformatics or Life Sciences, including fields, i.e., Biology, Molecular Biology, Genetics.
  • Two to five years' experience analyzing next-gen sequencing data (Illumina whole genomes or exomes): BCL to annotated variants
  • Two to five years' experience developing and maintaining pipelines for 24x7 automated bioinformatics analyses
  • Two to five years' experience integrating pipeline with the LIMS
  • Two to five years' experience working with and understanding of open source NGS tools like bwa, samtools, vcftools, picard, GATK, Freebayes, ANNOVAR, VEP, etc.
  • Two to five years' experience incorporating dbGaP, 1000 genomes, ExAC, Clinvar, OMIM, etc
  • Two to five years' experience with unix/linux operating system
  • Two to five years' experience software development using any of Ruby, Python, Perl, Bash
  • Two to five years' experience working with SVN, git
  • Two to five years' experience working with HPC scheduling systems such as Moab, TORQUE, LSF, OpenGrid Engine, etc.

Preferred Qualifications:

  • Demonstrated experience working in CNV and SV calling
  • Demonstrated experience in phenotype-genotype integration frameworks
  • Demonstrated experience working with cloud-based development or analysis
  • Demonstrated experience working in a CAP/CLIA environment
  • Demonstrated experience performing benchmarking of bioinformatics tools
  • Demonstrated experience developing and working with Docker and AWS images
  • Demonstrated experience in database development using MySQL, or any NoSQL flavors
  • Demonstrated experience in setting up and computing on a hadoop cluster
  • Demonstrated experience programming using C or Java


How to Apply

For more information and to apply:  



About Our Organization

The Rady Children's Institute for Genomic Medicine brings together world-class scientists and clinicians into a shared research infrastructure, one that will enable them to accelerate the translation and implementation of research discoveries for prevention, diagnosis, treatment, and ultimately cures for childhood diseases. Under the direction of world-renowned researcher Stephen Kingsmore, M.D., D.Sc., the Institute seeks to translate research findings into new clinical tests and treatments to improve patient outcomes, enhance the knowledge in this field among current and future healthcare providers and generate and share data and discoveries with other researchers.

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