Senior / Associate Principal Scientist, Bioinformatics, Oncology

AstraZeneca Pharmaceuticals
Job Location
Waltham, MA
Job Description

At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe. As a Senior / Associate Principal Scientist, Bioinformatics, Oncology in Waltham, MA you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives. IMED (Innovative Medicines and Early Development) focuses on scientific advances in small molecules, oligonucleotides and other emerging technologies and drug discovery platforms across our focus areas.
AstraZeneca's vision in Oncology is to help patients by redefining the cancer-treatment paradigm, with the aim of bringing six new cancer medicines to patients between 2013 and 2020. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and hematological cancers. As well as other tumor types, these are being targeted through four key platforms - immunotherapy, the genetic drivers of cancer and resistance, DNA damage repair, and antibody drug conjugates, underpinned by personalized healthcare and biomarker technologies.
The Oncology Bioinformatics group work within cross-disciplinary drug project teams throughout the discovery and translational pipeline, driving new target discovery, pre-clinical and clinical research.  The global group, currently 12 full time positions plus graduates and post-docs, spans the UK and US.


Main Duties and Responsibilities 
There is an exciting opportunity for a talented and motivated bioinformatician to take a prominent position within the group.  You will have a chance to become the local bioinformatics leader for immune-oncology and the tumor microenvironment. 
You will be responsible for:

•Performing innovative analytical research delivering actionable hypotheses to our portfolio. 
•Designing and influencing our immune-oncology strategy.
•Leading and growing our respective collaborative network in Boston and the US.
•Mentoring junior scientists to effectively support our portfolio. 
•Working closely with bioscience and translational science teams to understand where bioinformatics approaches can best impact their scientific and technical challenges.
•Enhancing a bioinformatics toolkit enabling our scientific community to maximise value from available public and proprietary data. 
•Finding new ways of interpreting, modelling and finding meaningful patterns in complex mutli-omic and phenotypic data. 
Essential Requirements 

•A relevant PhD; or a bachelor's degree plus 4 years of relevant training/experience. 
•Scientific emphasis in oncology or immunology.
•Technical emphasis in bioinformatics, computational biology or data science. 
•An additional 3 or more years applied experience in biotech, pharma, or drug discovery/translational research.
•An enthusiasm to explore non-traditional approaches to bring big data together in biologically meaningful ways.
•A thorough understanding of the contribution of bioinformatics to drug discovery.
•Deep understanding of the biological systems and signaling involved in human disease.
•A high-quality publication record representing valuable contributions to scientific projects.
•A collaborative spirit, and strong external reputation and scientific network.
•Technical expert in DNA-sequencing, 'omic and phenotypic data analysis and interpretation.
•Expert programming in R and Python.
•Skilled in effective communication of complex data to a non-expert. 

•Strength in mathematical /systems /modeling /machine learning based techniques.
•Experience harnessing data from: RWE; single cell platforms; real-time platforms.
•Expertize analyzing both somatic and germline genetics.
•Harnessing relational and unstructured data.
•Development of interactive computational tools. 
Next Steps - Apply today! 
To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.
AstraZeneca is an equal opportunity employer.  AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised. 

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