SCIENTIST, SYNTHETIC CHEMISTRY | GenomeWeb

SCIENTIST, SYNTHETIC CHEMISTRY

Organization
QIAGEN
Job Location
WALTHAM, MA
Job Description

We are seeking candidates who will assist in the design, synthesis, purification and scale up production of nucleotides. The successful candidate will be integral part of the NGS consumables department and will be responsible for design, implementation and optimization of synthesis pathways, scale up and development of SOPs as well as transferring manufacturing procedures to operations. This person will be interacting closely with the operations/manufacturing team as well as sequencing chemistry and enzyme development team.

 

The Scientist will:

 

  • Plan and execute complex synthesis of proprietary nucleotide triphosphates at micro to milimolar scale
  • Perform scale up of synthesis and purification of nucleotide triphopshates up to milimolar scale
  • Interface with manufacturing and operations to ensure transfer of procedures
  • Perform stability studies
  • Develop improvements in the design, synthesis and purification of nucleotide triphosphates
  • Contribute to the development of intellectual property
  • Collaborate closely with sequencing chemistry development group and other functional areas to meet project objectives
  • Write technical reports and scientific publications/posters, document experimental work and studies in compliance with QIAGEN requirements
  • Produce and maintain proper project documentation in accordance with internal and external requirements
Requirements
  • MS or PhD or equivalent in Organic Chemistry
  • Relevant industry experience: at least 3+ years industry experience
  • Strong hands-on experience in complex multi-step organic synthesis and synthesis purification of nucleotides
  • Experience with Sequencing by Synthesis technology
  • Experience with nucleotide triphosphate synthesis and purification at micro/milimolar scale
  • Extensive experience with chromatographic purification techniques, such as ion-exchange, reverse phase and analytical methods such as LC-MS and NMR
  • Proven ability to design, execute and correctly intepret complex experiments
  • Excellent verbal and writing skills, Excellent organizational skills
  • Strong technical writing and presentation skills, prepare data for presentation and present data in lab meetings and to internal collaborators
  • Good troubleshooting and problem solving skills
  • Experience with product development under design control is preferred
  • Minimal travel required (up to 10%)
How to Apply

Please kindly forward your application to:

Jessie Nguyen - Recruiting Specialist

jessie.nguyen@qiagen.com

 

About Our Organization

QIAGEN is the leading global provider of Sample to Insight solutions to transform biological materials into valuable molecular insights.

QIAGEN sample technologies isolate and process DNA, RNA and proteins from blood, tissue and other materials. Assay technologies make these biomolecules visible and ready for analysis. Bioinformatics software and knowledge bases interpret data to report relevant, actionable insights. Automation solutions tie these together in seamless and cost-effective molecular testing workflows.

QIAGEN provides these workflows to more than 500,000 customers around the world in Molecular Diagnostics (human healthcare), Applied Testing (forensics, veterinary testing and food safety), Pharma (pharmaceutical and biotechnology companies) and Academia (life sciences research).

As of June 30, 2015, QIAGEN employed approximately 4,400 people in over 35 locations worldwide. Further information can be found at http://www.qiagen.com.

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