Pacific Biosciences is seeking a highly motivated macromolecular modeler. The candidate will work within an interdisciplinary team to model macromolecular complexes, enzyme variants and their interactions with nucleotide analogs. The candidate will be able to draw on data from a wide variety of sources including crystallography, kinetic characterization and single molecule studies. She or he will use these data to both help design experiments that test mechanistic hypotheses and to design variants with desirable sequencing properties. The individual will be working in a fast-paced environment interacting with scientists from a wide variety of backgrounds. The title will be based on the selected individual’s experiences and determined at the offer stage.