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Scientist / Senior Scientist, Applications

Pacific Biosciences of California
Job Location
1305 O'Brien
Menlo Park, CA 94025
United States


PacBio offers a wide range of programs and services designed to help our employees grow in their career and achieve an appropriate work/life balance. We support the inclusion of all employees and take pride in being an excellent career choice.

Our compensation and benefits packages are designed to motivate and recognize quality work. While specific offerings vary by country, programs may include:

Healthcare and insurance plans

  • Medical, dental, and vision insurance plans
  • Life and accident insurance
  • Travel insurance
  • Disability insurance
  • Healthcare pre-tax spending accounts
  • Health savings account

Family benefits

  • Dependent pre-tax spending accounts
  • New parent leave

Commuting benefits

  • Commuter/parking pre-tax spending accounts
  • Shuttle service to and from local Caltrain stations
  • Bike lockers and shower facilities

Financial planning

  • Restricted stock units
  • 401(k) plan


  • Annual Health Fair
  • Employee assistance programs and work-life assistance
  • Fully equipped on-campus fitness center
  • Certified instructor-led fitness classes
Job Description

Pacific Biosciences seeks a Scientist / Senior Scientist position candidate with strong industrial molecular biology and instrumentation background to join our applications team.  The successful candidate will be responsible for methods development and execution of pilot projects.  The position primarily involves hands-on laboratory work in designing, developing and optimizing application workflows for single molecule sequencing.  The scientist will be working in a fast-paced environment, interacting with both internal and external scientists and field application specialists.

Key responsibilities include:

  • Design, develop and optimize DNA sequencing workflows for single molecule sequencing
  • Work closely with Bioinformaticians and R/D to develop end to end solutions
  • Running the Sequel and Sequel II instruments
  • Knowledge transfer of methodologies to field and support organizations
  • Presentations to commercial and R/D teams
  • Provide application training to technical experts including Field Applications Scientists and Technical Support
  • Support development of technical documentation and training materials
  • Generate sales collateral materials through white papers, application notes and method papers

All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.



  • M.S. or PhD in molecular biology, biochemistry, or related field (Appropriate experience carrying out molecular biology/biochemistry experiments at the Senior Research Associate level may qualify)
  • The ideal candidate will require minimal scientific guidance beyond project goals and can design/execute experiments independently
  • Understanding of human genetics, particularly classes of genetic variation and their intersections with cutting edge molecular technologies
  • Assay and technology development experience is highly desired
  • Experience with and understanding of high throughput sequencing instruments
  • Technical proficiency in general laboratory practices, biochemistry/molecular biology, including library construction and operation of robotic liquid handling equipment, next generation sequencing platforms.
  • Excellent record-keeping and careful attention-to-detail
  • Strong trouble-shooting abilities
  • Strong familiarity with the paper publication process and associated experimental design requirements
  • Ability to balance several projects and customers concurrently
  • Ability to work independently and collaboratively, with minimal supervision  
  • Strong presentation and communication skills  
  • Outstanding organizational and interpersonal skills  
  • Enjoy working closely with others as a member of an interdisciplinary team   
  • Ability to work under pressure     
  • A “can do” attitude and be flexible in a fast-paced start up environment   
  • Must be an intelligent individual with excellent work ethic, exceptional judgment, and unquestionable integrity  

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.

About Our Organization


Based in the heart of Silicon Valley, Pacific Biosciences provides sophisticated genomic analysis systems that deliver invaluable insights for scientists who strive to resolve complex genetic challenges.

In an effort to push the boundaries of molecular biology, our founders invented a new way to study the synthesis and regulation of DNA, RNA, and proteins. Harnessing advances in biochemistry, optics, nanofabrication, and more, we developed Single Molecule, Real-Time (SMRT) Sequencing technology. This powerful technology transforms the understanding of biological systems by enabling real-time analysis of biomolecules with single-molecule resolution.

PacBio sequencing offers the most comprehensive view of genomes, transcriptomes, and epigenomes — including the full spectrum of genetic variation — by providing the longest average read lengths, highest consensus accuracy, and most uniform coverage of any sequencing technology on the market today. Ideal for de novo genome assembly and genetic variation characterization of humansanimals, plants, and microbes, this system features high-performance optics, automated liquid handling, and an intuitive, intelligent operating system.

We are passionate about developing high-quality, innovative technologies and systems that impact areas of critical importance, including the diagnosis and treatment of disease and efforts to improve the world’s food and energy supply. We believe that our tools will lead to advances that will create long-lasting benefits for the world and its future.

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