OBJECTIVES OF THE PROGRAMME The overarching objectives of the Molecular Mechanisms and Biomarkers Group (MMB), within the Mechanisms of Carcinogenesis Section (MCA), are (1) to generate evidence-base for cancer prevention, by identifying novel mechanisms of carcinogenesis involving cellular pathways deregulated by specific environmental and life-style risk factors; (2) to develop and validate biomarkers of exposure, cancer risk or detection, alongside methodologies and resources applicable to population-based studies coordinated by IARC and external collaborators. The MMB Group employs experimental and molecular epidemiology studies (using cell-lines as models and human cancer specimens, respectively) to elucidate molecular events and biological processes involved in critical steps of cancer development and progression. Important parts of its strategy are investigations of causal links between specific environmental exposures and (epi)genetic alterations, identified through own as well as major international cancer genomics efforts. Functional studies of molecular pathways related to mutagenesis, DNA damage response/repair, cell proliferation, survival and death, and their critical alterations by specific environmental carcinogens are conducted in in vitro perturbation models by advanced methods of molecular and cellular biology. Tumour tissues and nucleic acids from cancer patient body fluids are exploited as sources of informative biomarkers. These activities collectively aim to contribute to evidence-based cancer prevention strategies. Purpose of the Position: Under the supervision of the Head of the MMB Group, the incumbent conducts own and collaborative research studies in these areas: laboratory research investigations of molecular alterations and cellular pathways involved in cancer development and progression, and their relationship with known or suspected etiological factors; discovery and validation of molecular biomarkers in the context of case-control and population-based cancer research studies. Organizational Context: The incumbent conducts and drives expert laboratory research within MCA/MMB, participates in initiatives for international collaborations and to identify opportunities for collaborative and inter-disciplinary research. Initiative and considerable degree of independence in promoting collaborations across IARC groups/sections is expected, in line with the strategic goals set for MCA/MMB. He/she also assists the MMB Group Head and MCA Section Head in overseeing scientific projects and other relevant activities and provides expert assistance/advice on relevant research projects at IARC and those conducted with external networks. Description of Duties: Within the framework of the MCA/MMB activities and under the guidance of MMB Group Head, the incumbent actively contributes to these areas: 1) Develop and conduct state-of-the-art laboratory research projects to elucidate the molecular bases of cancer phenotypes and to discover/validate molecular biomarkers of carcinogen exposure, disease risk and detection. 2) Develop and apply advanced methods of molecular biology, such as (epi)genomic profiling, applicable to sources of specimens associated with human population-based studies (biobanks). 3) Prepare and write scientific manuscripts, expert reviews, and reports on mechanistic and profiling studies. 4) Contribute to writing and write own grants to attract research funding from competitive sources in the relevant research areas. 5) Seek and develop internal and external collaborations where advanced molecular biology approaches may add value to research projects. 6) Provide technical guidance and supervision to students, visitors and trainees hosted by the MCA Section. 7) Assist in the organization of various scientific and/or technical activities related to on-going and future studies in cancer biology. 8) Perform other relevant duties as assigned by the Supervisor.