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Scientist, Mammalian Cell Biology

Job Location
5500 Central Ave.
Boulder, CO 80301
United States

Inscripta offers a competitive base salary, bonus plan, benefits package and stock options to all team members. Join us and work with a great team of people developing the world's first scalable platform for benchtop Digital Genome Engineering. At Inscripta we don’t just accept difference — we celebrate it, support it, and thrive on it for the benefit of our employees, our innovation, and our community. We are proud to be an equal opportunity workplace because the more inclusive we are as a company, the better our work will be. Inscripta is headquartered in Boulder, CO with offices in Pleasanton and San Diego, CA. This position can be located in either our Pleasanton, CA or Boulder, CO offices.

Job Description

Inscripta is developing the world's first scalable platform for benchtop Digital Genome Engineering. The company’s advanced CRISPR-based platform, consisting of an instrument, reagents, and software, will offer a fully automated workflow that enables multiplexed, trackable editing of cells at an unprecedented scale. Inscripta’s goal is to empower researchers whose gene editing research is stifled by current technical and licensing limitations. By providing this unique platform and engaging in collaborative business practices, such as making its MAD7 CRISPR nuclease free for research purposes, the company enables researchers to realize a new era of biological discovery. Due to rapid growth Inscripta has an opening for a Scientist, Mammalian Cell Biology, which can be located in either Pleasanton, CA or Boulder, CO.

As a Scientist in the Mammalian Cell Biology group you will be part of a diverse team focused on advancing the development of Inscripta’s cell engineering platform. The ideal candidate will develop CRISPR-based screening strategies to modulate gene expression in human primary cells and optimize genome engineering tools. In this role, you will be a leader in bringing new and innovative technologies and processes to market and will be responsible for planning, executing and reporting on experiments from a world class team of Engineers, Biologists, and Computer Scientists. 


  • Apply genome-wide CRISPR-based screening strategies in arrayed, pooled, and/or single-cell formats to interrogate cellular processes in primary human cells
  • Design, execute, and analyze experiments to advance Inscripta’s mammalian cell engineering program
  • Build assays that allow the genetic, phenotypic, and functional characterization of engineered mammalian iPSCs, primary immune cells, and/or other cell types
  • Develop and optimize protocols for high-throughput engineering of primary human cell types
  • Identify innovative solutions to solve key scientific challenges required for program success
  • Drive effective communication and collaboration within a multidisciplinary team to advance program objectives
  • Establish and maintain policies and procedures related to biosafety
  • Demonstrate integrity, positivity, and a team-oriented attitude and motivate others to do the same



Required Qualifications:

  • Ph.D in cell biology, immunology, biochemistry, developmental biology, molecular biology, or a related discipline
  • 2+ years in postdoc or industry setting
  • Expert in high-throughput genetic screening strategies 
  • Experience designing and cloning genome-wide-scale screening libraries (e.g. shRNA, CRISPRi/a sgRNA)
  • Direct experience working with genome editing tools in mammalian cells
  • Proficiency in viral delivery methods (lenti, rAAV, etc.)
  • Demonstrated ability to work both independently and within matrixed project teams
  • Excellent written and oral communication skills
  • Exceptional data analysis and quantitative skills
  • Track record of creativity and problem solving 


Preferred Qualifications:


  • Independence using liquid handling platforms
  • Deep understanding of genome integrity and mechanisms that promote mammalian genome stability
  • Experience with single cell genomic, transcriptomic, and proteomic analyses
  • Specialized expertise in the derivation, culture and characterization of primary human immune cells, human pluripotent stem cells, keratinocytes, hepatocytes, and/or neurons


About Our Organization

At Inscripta, we're more a calling than a company. Maybe it's our commitment to help feed, fuel and heal humanity. Making the MAD7™ CRISPR nuclease free for research purposes may not be typical in this industry, but it's typical for us. Our primary purpose is to empower scientists whose gene editing research is stifled by current technical and licensing limitations.

We want you to make bigger discoveries, faster and at unprecedented scale, experiencing those bold breakthroughs that the Onyx™ platform will provide. We live up to our press by 'walking the walk' every day, bringing you revolutionary tools that serve the greater good. Because Inscripta's more than a company, it's our calling.


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