Scientist, Bioinformatics (Molecular Profiling - Immuno-Oncology)

Regeneron Pharmaceuticals
Job Location
777 Old Saw Mill River Road
Tarrytown, NY 10591
Commensurate to experience

Health insurance, annual bonuses, stock option, 401k match, Pay Time Off, tuition reimbursement, and more. 

Job Description

Job ID: 6284BR

Location: Tarrytown, New York

Department: Molecular Profiling

The Molecular Profiling group is looking for a Scientist to analyze immuno-oncology (I/O) clinical, preclinical, and public profiling data to support I/O target mechanism studies, biomarker and target discovery & development, as well as implement and develop I/O data analysis pipeline using cutting-edge algorithms and statistically sound methodologies.

- Collaborate with I/O scientists in preclinical and clinical departments to design profiling experiments and draft data analysis plan
- Communicate results with I/O scientists, refine analysis based on feedback, and plan/prioritize follow-up experiments
- Prepare clear, concise and easy-to-understand presentations and documentations for collaborators, senior management and government agencies
- Analyze proprietary and public profiling data to support I/O targets and biomarker discovery
- Analyze proprietary tox profiling data to support Tox studies
- Analyze proprietary clinical profiling data to support Clinical studies
- Contribute to team effort of developing I/O data analysis strategies and establishing I/O data analysis best practices
- Participate in team effort of organizing and integrating proprietary and public molecular profiling data to enable data sharing and visualization for bench scientists


This position requires a minimum of a PhD in a related field, and preferably 2+ years postdoctoral experience.  Additional requirements include, but are not limited to:
- Expertise in immuno-oncology
- Expertise in NGS data analysis to detect gene expression, variants, copy number variation, fusion and alternative splicing
- Strong preference for R power users, especially DeSeq 6+
- Strong preference for experience in Single Cell Sequencing
- Experience with analyzing cancer profiling data in the public domain such as TCGA
- Experience with a variety of molecular profiling platforms such as microarray and NGS, and their data analysis best practices
- Familiarity with TCR repertoire sequence analysis, antigen prediction, modeling (e.g., machine learning) and network building (e.g. gene regulation networks): Keen interest and determination to be at the cutting-edge of algorithms and model building
- Familiarity with bioinformatics tools and software such as R/Matlab, Linux, Perl, Python, Ruby, Java, Ruby on Rails, SQL, web programming
- Ability to work both independently and collaboratively
- Team spirit and commitment to share and collaborate
- Excellent communication and presentation skills

Preferred skills:
- Experience with Structural and Computational Biology and Bioluminate is a plus

How to Apply

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

About Our Organization

Regeneron Pharmaceuticals is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including oncology, rheumatoid arthritis, asthma, atopic dermatitis, pain, and infectious diseases.

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