Scientist 1 - Microfluidic Biochemist

Job Location
5200 Illumina Way
San Diego, CA 92122
Competitive Base Salary + Bonus + RSU Equity
Job Description

Illumina is the only life sciences company developing genome-wide technologies for genotyping, gene expression and sequencing—the three cornerstones of modern genetic analysis.  By enabling studies of thousands of patient samples at once, our products set genetic discovery on fast forward. And we’re just getting started.

As a Scientist at Illumina in Reagents and Consumables Product Development you will work in a dynamic, team-oriented environment and help create genomic analysis tools used in the leading edge of research. You will work with multi-disciplinary teams to create cutting edge and robust new products and assays for the next generation sequencing platforms offered by Illumina. You will participate in the development of high-throughput assays and processes, optimize assays biochemistry and summarize progress.  The person in this role will troubleshoot the process in the middle between input and output of the cartridge, i.e. buffers, chemistry, PCR condition, enzymes degradation, etc.


  • Develop new products in fast-paced product development environment. Identify, evaluate, plan, and optimize research ideas leading to new robust assays and chemistries for next generation sequencing based on Illumina’s proprietary technologies
  • Explore new technologies and identify creative solutions to overcome current limitations
  • Identify new opportunities for innovative products using the company’s core technologies
  • Design, implement, analyze and present experiments to demonstrate feasibility of new methods and efficiently move products through pipeline
  • Optimize assay conditions to achieve commercial levels of stability, robustness, and performance
  • Create scalable infrastructure to support release of developed products
  • Be both a strong individual contributor as well as a collaborative team member.  Conduct clear and concise communication with colleagues (cross-functional) and supervisors through oral updates, written reports and technical meetings

Required Skills & Experience

  • PhD in Biochemistry or related scientific field
  • 3-5 years’ industrial experience in a scientific discipline or engineering is required, which may include post-doctoral work
  • Experience in biochemical or molecular assay development including sample input testing, buffer optimization, PCR design, data analysis
  • Experience in industrial product development including transitioning to manufacturing, scaling, and stability
  • Good understanding of how to troubleshoot and perform root cause analysis. Product design experience of microfluidic systems
  • Experienced with Design of Experiment (DOE) methodologies
  • Knowledge of technology development in a fast paced biotech environment
  • Extremely detail oriented with excellent laboratory and experimental skills

Preferred Skills & Experience

  • Excellent collaboration and troubleshooting skills specifically around buffers, chemistry, PCR condition, enzymes degradation, etc.
  • Background in electro-wetting, microfluidics or biochemistry in an oil environment is strongly preferred
  • Experience with next-generation sequencing biochemistry for Illumina sample prep, clustering, and SBS
  • Product development experience, including assay optimization, reagent development, integration and testing, transfer to production and documentation
  • Programming expertize and statistical methods for large dataset analysis (i.e., JMP, R, Python)
About Our Organization

EOE / Minorities / Females / Veterans / Disabled


About Illumina

Illumina is improving human health by unlocking the power of the genome.  If that inspires you, let’s talk. Having built a culture fueled by innovation, collaboration and openness, we’ve established ourselves as the global leader in DNA sequencing and array-based technologies. Our people and our technology change lives by driving advancements in life sciences, oncology, reproductive health, agriculture and other emerging markets. We are deeply passionate about what we do, because we know that our work has the power to improve lives.

We’re an established company with a track record of phenomenal growth. Our revenue grew from $10 million in 2002 to approximately $2.2 billion in 2015. Our growth isn’t just revenue; we’ve been hiring the best and the brightest. That’s why MIT ranked Illumina near the top of its World’s Smartest Companies list three years running, including #1 in 2014. If you thrive in a brilliant, fast-paced, and mission-driven environment, Illumina is the place for you – imagine the possibilities.

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