EMBL-EBI is a world-leader in archiving and disseminating 3D biomacromolecular and cellular structure data. The Cellular Structure & 3D Bioimaging team plays a key role in the dissemination of 3D electron microscopy (EM) data through the EMDB (emdb-empiar.org) and EMPIAR (empiar.org) public archives. We develop and provide advanced tools and web-resources for searching, analyzing and visualizing structural data for the benefit of structural biologists and the wider scientific community. The team consists of an international and inter-disciplinary mix of professionals (scientists and IT specialists) and we are looking to augment the team with a developer to work on an exciting Welcome Trust funded project to develop validation tools for cryo-electron microscopy. This is a joint project with the research groups of Garib Murshudov (MRC-LMB), Elena Orlova (Birkbeck Univeristy of London), Alan Roseman (University of Manchester), Peter Rosenthal (Francis Crick), Maya Topf (Birkbeck University of London), and Martyn Winn (STFC).
The post holder will:
- Expand and improve the repertoire of stand-alone validation servers for the EM community offered by EMBL-EBI, such as the Fourier Shell Correlation server (emdb-empiar.org/fsc) and the Tilt Pair Validation server (emdb-empiar.org/tiltpair)
- Expand the visual analysis web service (e.g., emdb-empiar.org/emd-984/analysis) that provides validation information on EMDB entries with the components to be developed by project partners
- Develop reporting formats for depositing validation information, e.g., from local resolution methods such as ResMap.